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Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

Research output: Contribution to journalArticle

Original languageEnglish
JournalCrohn's and Colitis 360
DOIs
DateAccepted/In press - 12 Mar 2020

Abstract

Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD).

Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes.

Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn’s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD.

Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD.

    Research areas

  • smoking, inflammatory bowel disease, Mendelian randomisation, UK Biobank

    Structured keywords

  • Physical and Mental Health
  • Tobacco and Alcohol

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  • Full-text PDF (accepted author manuscript)

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  • Supplementary information PDF

    Accepted author manuscript, 86.6 KB, PDF document

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