Exploring variability in basal ganglia connectivity with functional MRI in healthy aging

Ludovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C. Klein, Mika Kivimäki, Archana Singh-Manoux, Michele T. Hu, Klaus P. Ebmeier, Clare E. Mackay*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

13 Citations (Scopus)
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Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults.
We explored the relationship between FC in the BGN and variables related to demographics, impulsive behaviour, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches.
Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of ageing on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.
Original languageEnglish
Pages (from-to)1822–1827
Number of pages6
JournalBrain Imaging and Behavior
Issue number6
Early online date13 Feb 2018
Publication statusPublished - Dec 2018

Structured keywords

  • Brain Imaging


  • Basal ganglia
  • Dopamine
  • Functional connectivity
  • Healthy aging
  • Parkinson’s disease
  • Resting state fMRI


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