Exploring variability in basal ganglia connectivity with functional MRI in healthy aging

Ludovica Griffanti; Philipp Stratmann; Michal Rolinski; Nicola Filippini; Enikő Zsoldos; Abda Mahmood; Giovanna Zamboni; Gwenaëlle Douaud; Johannes C. Klein; Mika Kivimäki; Archana Singh-Manoux; Michele T. Hu; Klaus P. Ebmeier; Clare E. Mackay

doi:10.1007/s11682-018-9824-1

Exploring variability in basal ganglia connectivity with functional MRI in healthy aging

Ludovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C. Klein, Mika Kivimäki, Archana Singh-Manoux, Michele T. Hu, Klaus P. Ebmeier, Clare E. Mackay^*

^*Corresponding author for this work

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Abstract

Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults.
We explored the relationship between FC in the BGN and variables related to demographics, impulsive behaviour, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches.
Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of ageing on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.

Original language	English
Pages (from-to)	1822–1827
Number of pages	6
Journal	Brain Imaging and Behavior
Volume	12
Issue number	6
Early online date	13 Feb 2018
DOIs	https://doi.org/10.1007/s11682-018-9824-1
Publication status	Published - Dec 2018

Structured keywords

Brain Imaging

Keywords

Basal ganglia
Dopamine
Functional connectivity
Healthy aging
Parkinson’s disease
Resting state fMRI

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Griffanti, L., Stratmann, P., Rolinski, M., Filippini, N., Zsoldos, E., Mahmood, A., Zamboni, G., Douaud, G., Klein, J. C., Kivimäki, M., Singh-Manoux, A., Hu, M. T., Ebmeier, K. P., & Mackay, C. E. (2018). Exploring variability in basal ganglia connectivity with functional MRI in healthy aging. Brain Imaging and Behavior, 12(6), 1822–1827. https://doi.org/10.1007/s11682-018-9824-1

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title = "Exploring variability in basal ganglia connectivity with functional MRI in healthy aging",

abstract = "Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults.We explored the relationship between FC in the BGN and variables related to demographics, impulsive behaviour, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches.Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of ageing on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.",

keywords = "Basal ganglia, Dopamine, Functional connectivity, Healthy aging, Parkinson{\textquoteright}s disease, Resting state fMRI",

author = "Ludovica Griffanti and Philipp Stratmann and Michal Rolinski and Nicola Filippini and Enik{\H o} Zsoldos and Abda Mahmood and Giovanna Zamboni and Gwena{\"e}lle Douaud and Klein, {Johannes C.} and Mika Kivim{\"a}ki and Archana Singh-Manoux and Hu, {Michele T.} and Ebmeier, {Klaus P.} and Mackay, {Clare E.}",

year = "2018",

month = dec,

doi = "10.1007/s11682-018-9824-1",

language = "English",

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Griffanti, L, Stratmann, P, Rolinski, M, Filippini, N, Zsoldos, E, Mahmood, A, Zamboni, G, Douaud, G, Klein, JC, Kivimäki, M, Singh-Manoux, A, Hu, MT, Ebmeier, KP & Mackay, CE 2018, 'Exploring variability in basal ganglia connectivity with functional MRI in healthy aging', Brain Imaging and Behavior, vol. 12, no. 6, pp. 1822–1827. https://doi.org/10.1007/s11682-018-9824-1

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T1 - Exploring variability in basal ganglia connectivity with functional MRI in healthy aging

AU - Griffanti, Ludovica

AU - Stratmann, Philipp

AU - Rolinski, Michal

AU - Filippini, Nicola

AU - Zsoldos, Enikő

AU - Mahmood, Abda

AU - Zamboni, Giovanna

AU - Douaud, Gwenaëlle

AU - Klein, Johannes C.

AU - Kivimäki, Mika

AU - Singh-Manoux, Archana

AU - Hu, Michele T.

AU - Ebmeier, Klaus P.

AU - Mackay, Clare E.

PY - 2018/12

Y1 - 2018/12

N2 - Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults.We explored the relationship between FC in the BGN and variables related to demographics, impulsive behaviour, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches.Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of ageing on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.

AB - Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults.We explored the relationship between FC in the BGN and variables related to demographics, impulsive behaviour, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches.Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of ageing on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging.

KW - Basal ganglia

KW - Dopamine

KW - Functional connectivity

KW - Healthy aging

KW - Parkinson’s disease

KW - Resting state fMRI

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U2 - 10.1007/s11682-018-9824-1

DO - 10.1007/s11682-018-9824-1

M3 - Article (Academic Journal)

C2 - 29442271

AN - SCOPUS:85041902801

SN - 1931-7557

VL - 12

SP - 1822

EP - 1827

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - 6

ER -

Exploring variability in basal ganglia connectivity with functional MRI in healthy aging

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