Expression of Prolyl hydroxylases 2 and 3 in chick embryos

Jake Barber, Nobue Itasaki

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
274 Downloads (Pure)

Abstract

Hypoxic cellular response is crucial for normal development as well as in
pathological conditions in order to tolerate low oxygen. The response is mediated by Hypoxia Inducible Factors (HIFs), where the α-subunit of HIF is stabilised and able to function only in low oxygen. Prolyl hydroxylases (PHDs) are oxygen dependent dioxygenase enzymes that hydroxyrate HIF-α leading to HIF degradation. Thus PHDs function as an oxygen sensor for the function of HIFs. Here we describe the mRNA expression pattern of PHDs in chick embryos. Up to embryonic day 2, PHDs are weak without specific localisation, whereas from day 3 localised expression was observed in the eye, branchial arches and dermomyotome. Later in the limb development PHDs were expressed in the perichondral mesenchyme, excluded from the developing limb cartilages.
Original languageEnglish
Pages (from-to)97-102
Number of pages21
JournalGene Expression Patterns
Volume21
Issue number2
Early online date8 Apr 2016
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Prolyl Hydroxyrase
  • EGLN
  • Hypoxia
  • HIF
  • chick embryo

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