Background: Observational studies and registry data suggest improved clinical
outcomes with extended treatment time (TT) on haemodialysis (HD). This has not been
rigorously studied for in-centre day time HD. We report the effects of extended TT on blood
pressure (BP), time to recovery (TTR) and dialysis related parameters.
Methods: Randomised cross-over study of 29 in-centre HD patients with extended TT
of 6 hrs or standard TT of 4 hrs for a period of 24 wks with a 4wk washout period between
the two arms (NCT01721421).
Results: 29 HD patients (27 male, mean age 65.2 ± 15.2 years, pre study TT 4.6 ±0.4hrs)were
assessed.Pre dialysis mean arterial pressure (MAP) was signifi cantly reduced on the 6 hr
arm accompanied by a signifi cant decrease in the number of BP drugs. Intra-dialytic weight
gain (IDWG) was not signifi cantly changed on either treatment arm, but ultra-filtration rate
(UFR) was signifi cantly lower on the extended TT arm. This could explain the signifi cantly
lower TTR during the 6 hr arm.
Conclusions: This randomised trial confi rms the positive effects of extended TT on
BP control achieved with lowered UFR and less reliance on antihypertensive agents. The
improvement in TTR may serve to promote the acceptability of extended TT to in-centre
|Conference||American Society of Nephrology, Kidney Week 2014|
|Period||11/11/14 → 16/11/14|