Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

Philippe Pasdois, Joanne Elizabeth Parker, Andrew Philip Halestrap

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Abstract

The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.
Original languageEnglish
Pages (from-to)e005645
JournalJournal of the American Heart Association
Volume2
Issue number1
DOIs
Publication statusPublished - 2012

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