TY - JOUR
T1 - Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion
AU - Pasdois, Philippe
AU - Parker, Joanne Elizabeth
AU - Halestrap, Andrew Philip
PY - 2012
Y1 - 2012
N2 - The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.
AB - The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.
U2 - 10.1161/JAHA.112.005645
DO - 10.1161/JAHA.112.005645
M3 - Article (Academic Journal)
C2 - 23525412
SN - 2047-9980
VL - 2
SP - e005645
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 1
ER -