Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

Philippe Pasdois; Joanne Elizabeth Parker; Andrew Philip Halestrap

doi:10.1161/JAHA.112.005645

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

Philippe Pasdois, Joanne Elizabeth Parker, Andrew Philip Halestrap

Research output: Contribution to journal › Article (Academic Journal) › peer-review

80 Citations (Scopus)

Abstract

The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.

Original language	English
Pages (from-to)	e005645
Journal	Journal of the American Heart Association
Volume	2
Issue number	1
DOIs	https://doi.org/10.1161/JAHA.112.005645
Publication status	Published - 2012

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@article{699d07f01f804e929e884b5d247ad9fb,

title = "Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion",

abstract = "The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.",

author = "Philippe Pasdois and Parker, \{Joanne Elizabeth\} and Halestrap, \{Andrew Philip\}",

year = "2012",

doi = "10.1161/JAHA.112.005645",

language = "English",

volume = "2",

pages = "e005645",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "American Heart Association Inc.",

number = "1",

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Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion. / Pasdois, Philippe; Parker, Joanne Elizabeth; Halestrap, Andrew Philip.
In: Journal of the American Heart Association, Vol. 2, No. 1, 2012, p. e005645.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

AU - Pasdois, Philippe

AU - Parker, Joanne Elizabeth

AU - Halestrap, Andrew Philip

PY - 2012

Y1 - 2012

N2 - The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.

AB - The mechanisms by which ischemic preconditioning (IP) inhibits mitochondrial permeability transition pore opening and, hence, ischemia-reperfusion injury remain unclear. Here we investigate whether and how mitochondria-bound hexokinase 2 (mtHK2) may exert part of the cardioprotective effects of IP.

U2 - 10.1161/JAHA.112.005645

DO - 10.1161/JAHA.112.005645

M3 - Article (Academic Journal)

C2 - 23525412

SN - 2047-9980

VL - 2

SP - e005645

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 1

ER -

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

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