Extracellular matrix and smooth muscle cells

S. J. George*, J. L. Johnson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

4 Citations (Scopus)


The arterial wall is a highly organised structure of cells and extracellular matrix (ECM) (see review by Adizugel et al. [1]). The ECM is synthesized by the VSMCs within the arterial wall, which then interact with the ECM through cell-matrix contacts. Many different forms of ECM are present in the arterial wall including both collagenous and non-collagenous proteins. In the intima, endothelial cells sit upon a layer of basement membrane composed of laminin, nidogen, perlecan, fibronectin and type IV collagen. In the media, VSMCs are surrounded by basement membrane, which is in turn embedded in fibrillar collagens type I, III and V, collagen type XVIII, fibronectin, and glycoproteins including proteoglycans and cartilage oligomeric matrix protein (COMP, thrombospondin 5) [2, 3].

Original languageEnglish
Title of host publicationInflammation and Atherosclerosis
PublisherSpringer Vienna
Number of pages26
ISBN (Print)9783709103388, 3709103371, 9783709103371
Publication statusPublished - 1 Apr 2012


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