Extranuclear SUMOylation in Neurons

Jeremy Henley*, Ruth Carmichael, Kevin Wilkinson

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

25 Citations (Scopus)
362 Downloads (Pure)

Abstract

Post-translational modification of substrate proteins by SUMO conjugation regulates a diverse array of cellular processes. While predominantly a nuclear protein modification, there is a growing appreciation that SUMOylation of proteins outside the nucleus plays direct roles in controlling synaptic transmission, neuronal excitability, and adaptive responses to cell stress. Furthermore, alterations in protein SUMOylation are observed in a wide range of neurological and neurodegenerative diseases, and several extranuclear disease-associated proteins have been shown to be directly SUMOylated. Here, focusing mainly on SUMOylation of synaptic and mitochondrial proteins, we outline recent developments and discoveries, and present our opinion as to the most exciting avenues for future research to define how SUMOylation of extranuclear proteins regulates neuronal and synaptic function.

Original languageEnglish
Pages (from-to)198-210
Number of pages13
JournalTrends in Neurosciences
Volume41
Issue number4
Early online date9 Mar 2018
DOIs
Publication statusPublished - Apr 2018

Keywords

  • AMPA receptor
  • dynamin-related protein 1 (Drp1)
  • fission
  • kainate receptor
  • mitochondria
  • post-translational modification
  • SUMO
  • synapse

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