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Fabrication of Micropatterned Dipeptide Hydrogels by Acoustic Trapping of Stimulus-Responsive Coacervate Droplets

Research output: Contribution to journalArticle

Original languageEnglish
Article number1800739
Number of pages10
Issue number26
Early online date3 May 2018
DateAccepted/In press - 6 Apr 2018
DateE-pub ahead of print - 3 May 2018
DatePublished (current) - 27 Jun 2018


Acoustic standing waves offer an excellent opportunity to trap and spatially manipulate colloidal objects. This noncontact technique is used for the in situ formation and patterning in aqueous solution of 1D or 2D arrays of pH-responsive coacervate microdroplets comprising poly(diallyldimethylammonium) chloride and the dipeptide N-fluorenyl-9-methoxy-carbonyl-D-alanine-D-alanine. Decreasing the pH of the preformed droplet arrays results in dipeptide nanofilament self-assembly and subsequent formation of a micropatterned supramolecular hydrogel that can be removed as a self-supporting monolith. Guest molecules such as molecular dyes, proteins, and oligonucleotides are sequestered specifically within the coacervate droplets during acoustic processing to produce micropatterned hydrogels containing spatially organized functional components. Using this strategy, the site-specific isolation of multiple enzymes to drive a catalytic cascade within the micropatterned hydrogel films is exploited.

    Research areas

  • acoustic trapping, coacervates, hydrogels, micropatterning, self-assembly

    Structured keywords

  • Bristol BioDesign Institute
  • BrisSynBio

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