Facial Expressions Evoke Differential Neural Coupling in Macaques

Ning Liu, Fadila Hadj-Bouziane, Rosalyn Moran, Leslie G Ungerleider, Alumit Ishai

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

In humans and monkeys, face perception activates a distributed cortical network that includes extrastriate, limbic, and prefrontal regions. Within face-responsive regions, emotional faces evoke stronger responses than neutral faces ("valence effect"). We used fMRI and Dynamic Causal Modeling (DCM) to test the hypothesis that emotional faces differentially alter the functional coupling among face-responsive regions. Three monkeys viewed conspecific faces with neutral, threatening, fearful, and appeasing expressions. Using Bayesian model selection, various models of neural interactions between the posterior (TEO) and anterior (TE) portions of inferior temporal (IT) cortex, the amygdala, the orbitofrontal (OFC), and ventrolateral prefrontal cortex (VLPFC) were tested. The valence effect was mediated by feedback connections from the amygdala to TE and TEO, and feedback connections from VLPFC to the amygdala and TE. Emotional faces were associated with differential effective connectivity: Fearful faces evoked stronger modulations in the connections from the amygdala to TE and TEO; threatening faces evoked weaker modulations in the connections from the amygdala and VLPFC to TE; and appeasing faces evoked weaker modulations in the connection from VLPFC to the amygdala. Our results suggest dynamic alterations in neural coupling during the perception of behaviorally relevant facial expressions that are vital for social communication.

Original languageEnglish
Article numberbhv345
Pages (from-to)1524–1531
Number of pages8
JournalCerebral Cortex
Volume27
Issue number2
Early online date11 Jan 2016
DOIs
Publication statusPublished - Feb 2017

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