Factors Affecting the Nuclear Localization of β-Catenin in Normal and Malignant Tissue 

Rhys G. Morgan*, Jenna Ridsdale, Alex Tonks, Richard L. Darley

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Abstract

The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, beta-catenin. In particular, the nuclear localization of beta-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling beta-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of beta-catenin and how they are relevant to cancer. (C) 2014 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)1351-1361
Number of pages11
JournalJournal of Cellular Biochemistry
Volume115
Issue number8
DOIs
Publication statusPublished - 10 Mar 2014

Bibliographical note

© 2014 Wiley Periodicals, Inc.

Keywords

  • Wnt
  • beta-CATENIN
  • NUCLEAR TRANSLOCATION/LOCALIZATION
  • LEUKEMIA
  • CANCER
  • ADENOMATOUS POLYPOSIS-COLI
  • ACUTE MYELOID-LEUKEMIA
  • TYROSINE PHOSPHORYLATION
  • COLORECTAL-CANCER
  • INTRACELLULAR TRANSLOCATION
  • SUBCELLULAR-LOCALIZATION
  • TRANSCRIPTIONAL ACTIVITY
  • ANDROGEN RECEPTOR
  • GENE-EXPRESSION
  • INVASION FRONT

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