Abstract
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, beta-catenin. In particular, the nuclear localization of beta-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling beta-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of beta-catenin and how they are relevant to cancer. (C) 2014 Wiley Periodicals, Inc.
Original language | English |
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Pages (from-to) | 1351-1361 |
Number of pages | 11 |
Journal | Journal of Cellular Biochemistry |
Volume | 115 |
Issue number | 8 |
DOIs | |
Publication status | Published - 10 Mar 2014 |
Bibliographical note
© 2014 Wiley Periodicals, Inc.Keywords
- Wnt
- beta-CATENIN
- NUCLEAR TRANSLOCATION/LOCALIZATION
- LEUKEMIA
- CANCER
- ADENOMATOUS POLYPOSIS-COLI
- ACUTE MYELOID-LEUKEMIA
- TYROSINE PHOSPHORYLATION
- COLORECTAL-CANCER
- INTRACELLULAR TRANSLOCATION
- SUBCELLULAR-LOCALIZATION
- TRANSCRIPTIONAL ACTIVITY
- ANDROGEN RECEPTOR
- GENE-EXPRESSION
- INVASION FRONT