Factors Associated with Bovine Neonatal Pancytopenia (BNP) in Calves: A Case-Control Study

Sarah L. Lambton*, Adrian D. Colloff, Richard P. Smith, George L. Caldow, Sandra F. E. Scholes, Kim Willoughby, Fiona Howie, Johanne Ellis-Iversen, Graham David, Alasdair J. C. Cook, Andrew Holliman

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)

Abstract

Bovine neonatal pancytopenia (BNP; previously known as idiopathic haemorrhagic diathesis and commonly known as bleeding calf syndrome) is a novel haemorrhagic disease of young calves which has emerged in a number of European countries during recent years. Data were retrospectively collected during June to November 2010 for 56 case calves diagnosed with BNP between 17 March and 7 June of the same year. These were compared with 58 control calves randomly recruited from herds with no history of BNP. Multivariable logistic regression analysis showed that increased odds of a calf being a BNP case were associated with its dam having received PregSure (R) BVD (Pfizer Animal Health) vaccination prior to the birth of the calf (odds ratio (OR) 40.78, p

Original languageEnglish
Article number34183
Number of pages7
JournalPLoS ONE
Volume7
Issue number5
DOIs
Publication statusPublished - 11 May 2012

Keywords

  • HEMORRHAGIC DIATHESIS
  • HAEMOLYTIC DISEASE
  • ANTIBODIES
  • NEWBORN
  • HERD

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