Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease

N Tunstall, MJ Owen, J Williams, F Rice, S Carty, S Lillystone, L Fraser, P Kehoe, D Neill, V Rudrasingham, P Sham, S Lovestone

Research output: Contribution to journalArticle (Academic Journal)peer-review

53 Citations (Scopus)

Abstract

BACKGROUND: Alzheimer's disease manifests considerable heterogeneity, the cause of which is unknown. AIMS: To determine the familial (genotypic) influence on phenomenology (phenotype) in Alzheimer's disease. METHOD: Affected sibling pairs with Alzheimer's disease were assessed for a range of cognitive and non-cognitive symptoms. Resemblance for phenotypic characteristics was estimated using intraclass correlations for continuous traits and by pairwise concordance for dichotomous traits. The relationship between age of onset and APOE genotype was examined using linear regression analysis. RESULTS: Significant familial effects on age of onset (intraclass correlation 0.41) and mood state (intraclass correlation 0.26), and a relatively high pairwise concordance for agitation (excess concordance 0.1) were found. The APOE locus was found to account for 4% of the variance in age of onset. CONCLUSIONS: Substantial familial influence on age of onset, depression and agitation suggests that genotype does influence phenotype in Alzheimer's disease. Establishing the molecular basis for this phenotypic variation may prove relevant to other neuropsychiatric disorders.
Translated title of the contributionFamilial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease
Original languageEnglish
Pages (from-to)156 - 159
Number of pages4
JournalBritish Journal of Psychiatry
Volume176
DOIs
Publication statusPublished - Feb 2000

Fingerprint

Dive into the research topics of 'Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease'. Together they form a unique fingerprint.

Cite this