Abstract
Fascins, a family of actin-bundling proteins, are expressed in a spatially and temporally restricted manner during development and often in cancer. Fascin 1 has a clear role in cell migration in vitro, but its role in vivo in mammals is not well understood. Here, we investigate the role of fascin 1 in the melanocyte lineage and in melanoma cells. Fascin 1 knockout causes hypopigmentation in adult mice owing to migration and cell cycle progression defects in melanoblasts, the melanocyte precursor cell. Study of live embryo skin explants reveals that E14.5 fascin 1-null melanoblasts migrate slower, and generate fewer and thinner pseudopods. By contrast, fascin 1 expression drives faster migration and lamellipodia protrusion in melanocytes in vitro. In addition, fascin 1 depletion retards melanoblast proliferation in vivo and melanoma cell growth in vitro. These data indicate that fascin 1 not only promotes cell migration in mouse melanocytes but it also has a role in growth and cell cycle progression.
| Original language | English |
|---|---|
| Pages (from-to) | 2203-11 |
| Number of pages | 9 |
| Journal | Development (Cambridge) |
| Volume | 140 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - May 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Animals
- Carrier Proteins/genetics
- Cell Cycle
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Gene Expression Regulation, Developmental
- Humans
- Melanocytes/cytology
- Melanoma/metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microfilament Proteins/genetics
- Pigmentation
- Skin/pathology
- Time Factors
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