Feasibility and effectiveness of transcatheter aortic valve implantation in adults with congenital heart disease

Sarah Moharem-Elgamal, Michael Yeong, Sundar Veerappan, Nathan E Manghat, Radwa Bedair, Stephen Dorman, Massimo Caputo, Mark C K Hamilton, Mark Turner*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review


This study sought to evaluate the feasibility and effectiveness of TAVI for treatment of aortic stenosis in the ACHD population.

Methods and results
Review of 802 patients that underwent TAVI from January 2008 to November 2019. 13 ACHD patients with different underlying congenital anatomy were identified (isolated bicuspid aortic valve was excluded and not defined as ACHD). The main endpoints were: paravalvular aortic regurgitation> grade 2 post-procedure, and all-cause 30-day mortality. Periprocedural and post-procedural complications were defined according to the UK TAVI registry. Median age was 66.7 years (range 29–84 years). Eleven patients had severe aortic stenosis (AS), 1 had both severe AS and severe aortic regurgitation (AR) and 1 had severe AR. Median hospital stay was 9 days (range 6–28 days). One patient required a pacemaker post-TAVI. No mortality or paravalvular AR > grade 2 at 30-days. Twelve patients had a reduction in NYHA class on their first post TAVI follow-up.

TAVI is viable option as an alternative to surgery for ACHD patients. Further experience with the use of TAVI in the ACHD patients is required to assess long-term outcomes in this unique group of patients.

Original languageEnglish
Journal International Journal of Cardiology Congenital Heart Disease
Early online date17 Mar 2021
Publication statusE-pub ahead of print - 17 Mar 2021


  • Aortic valve disease
  • Adult congenital heart disease
  • Transcatheter aortic valve replacement


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