Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

Duleeka Knipe; Channa Jayasumana; Sisira Siribaddana; Chamil Priyadarshana; Melissa Pearson; David Gunnell; Chris Metcalfe; Manolis  Tzatzarakis; A  Tsatsakis

doi:10.1016/j.envres.2016.02.011

Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

Duleeka Knipe, Channa Jayasumana, Sisira Siribaddana, Chamil Priyadarshana, Melissa Pearson, David Gunnell, Chris Metcalfe, Manolis Tzatzarakis, A Tsatsakis

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Abstract

Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Environmental Research
Volume	147
Early online date	16 Feb 2016
DOIs	https://doi.org/10.1016/j.envres.2016.02.011
Publication status	Published - May 2016

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title = "Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka",

abstract = "Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.",

author = "Duleeka Knipe and Channa Jayasumana and Sisira Siribaddana and Chamil Priyadarshana and Melissa Pearson and David Gunnell and Chris Metcalfe and Manolis Tzatzarakis and A Tsatsakis",

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doi = "10.1016/j.envres.2016.02.011",

language = "English",

volume = "147",

pages = "207--211",

journal = "Environmental Research",

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TY - JOUR

T1 - Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

AU - Knipe, Duleeka

AU - Jayasumana, Channa

AU - Siribaddana, Sisira

AU - Priyadarshana, Chamil

AU - Pearson, Melissa

AU - Gunnell, David

AU - Metcalfe, Chris

AU - Tzatzarakis, Manolis

AU - Tsatsakis, A

PY - 2016/5

Y1 - 2016/5

N2 - Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.

AB - Measuring chronic pesticide exposure is important in order to investigate the associated health effects. Traditional biological samples (blood/urine) are difficult to collect, store and transport in large epidemiological studies in settings such as rural Asia. We assessed the acceptability of collecting hair samples from a rural Sri Lankan population and found that this method of data collection was feasible. We also assessed the level of non-specific metabolites (DAPS) of organophosphate pesticides in the hair samples. The median concentration (pg/mg) of each DAP was: diethyl phosphate: 83.3 (IQI 56.0, 209.4); diethyl thiophosphate: 34.7 (IQI 13.8, 147.9); diethyl dithiophosphate: 34.5 (IQI 23.4, 55.2); and dimethyl phosphate: 3 (IQI 3, 109.7). Total diethylphosphates were recovered in >80% of samples and were positively correlated with self-reported pesticide exposure.

U2 - 10.1016/j.envres.2016.02.011

DO - 10.1016/j.envres.2016.02.011

M3 - Article (Academic Journal)

C2 - 26894816

SN - 0013-9351

VL - 147

SP - 207

EP - 211

JO - Environmental Research

JF - Environmental Research

ER -

Feasibility of hair sampling to assess levels of organophosphate metabolites in rural areas of Sri Lanka

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