Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment

Angie Hibbert, Tim Gruffydd-Jones, Esther L. Barrett, Michael J. Day, Andrea M. Harvey

Research output: Contribution to journalArticle (Academic Journal)peer-review

33 Citations (Scopus)

Abstract

This study reports the scintigraphy, histopathology sole treatment with high-close radioactive iodine and outcome of eight cases of feline thyroid carcinoma. Scintigraphic findings were variable and in 7/8 cases scintigraphic features could not reliably distinguish whether the thyroid tissue was malignant. Histopathology revealed typical criteria of malignancy in all cases, with mitotic activity described most frequently (7/8 cases), followed by infiltration of local tissues (4/8 cases). Cellular pleomorphism was infrequently observed. Single high-dose (1100 MBq I-131) radicliodine therapy was successful in 6/8 cases, with complete resolution of hyperthyroidism, and was associated with prolonged survival times (181-2381 days). Sole treatment with high-dose radioiodine is a safe and effective treatment for functional thyroid carcinoma. The prognosis for feline thyroid carcinoma successfully treated with radioiodine is good, with extended survival times commonly achieved. (C) 2008 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)116-124
Number of pages9
JournalJournal of Feline Medicine and Surgery
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2009

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