Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats

Julia A. Beatty; Ryan M. Troyer; Scott Carver; Vanessa R. Barrs; Fanny Espinasse; Oliver Conradi; Kathryn Stutzman-Rodriguez; Cathy C. Chan; Séverine Tasker; Michael R. Lappin; Sue VandeWoude

doi:10.1016/j.virol.2014.05.007

Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats

Julia A. Beatty^*, Ryan M. Troyer, Scott Carver, Vanessa R. Barrs, Fanny Espinasse, Oliver Conradi, Kathryn Stutzman-Rodriguez, Cathy C. Chan, Séverine Tasker, Michael R. Lappin, Sue VandeWoude

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

40 Citations (Scopus)

Abstract

Felis catus gammaherpesvirus 1 (FcaGHV1), recently discovered in the USA, was detected in domestic cats in Australia (11.4%, 95% confidence interval 5.9-19.1, n=110) and Singapore (9.6%, 95% confidence interval 5.9-14.6, n=176) using qPCR. FcaGHV1 qPCR positive cats were 2.8 times more likely to be sick than healthy. Risk factors for FcaGHV1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (FIV) or feline leukaemia virus. FcaGHV1 DNA was detected in multiple tissues from infected cats with consistently high virus loads in the small intestine. FcaGHV1 viral load was significantly higher in FIV-infected cats compared with matched controls, mimicking increased Epstein-Barr virus loads in human immunodeficiency virus-infected humans. FcaGHV1 is endemic in distant geographic regions and is associated with being sick and with coinfections. Horizontal transmission of FcaGHV1 is supported, with biting being a plausible route. A pathogenic role for FcaGHV1 in domestic cats is supported.

Original language	English
Pages (from-to)	100-107
Number of pages	8
Journal	Virology
Volume	460-461
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2014.05.007
Publication status	Published - 1 Jan 2014

Keywords

Copathogen
Feline
Gammaherpesvirus
Molecular epidemiology
Transmission

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats",

abstract = "Felis catus gammaherpesvirus 1 (FcaGHV1), recently discovered in the USA, was detected in domestic cats in Australia (11.4%, 95% confidence interval 5.9-19.1, n=110) and Singapore (9.6%, 95% confidence interval 5.9-14.6, n=176) using qPCR. FcaGHV1 qPCR positive cats were 2.8 times more likely to be sick than healthy. Risk factors for FcaGHV1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (FIV) or feline leukaemia virus. FcaGHV1 DNA was detected in multiple tissues from infected cats with consistently high virus loads in the small intestine. FcaGHV1 viral load was significantly higher in FIV-infected cats compared with matched controls, mimicking increased Epstein-Barr virus loads in human immunodeficiency virus-infected humans. FcaGHV1 is endemic in distant geographic regions and is associated with being sick and with coinfections. Horizontal transmission of FcaGHV1 is supported, with biting being a plausible route. A pathogenic role for FcaGHV1 in domestic cats is supported.",

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AU - Beatty, Julia A.

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AU - Espinasse, Fanny

AU - Conradi, Oliver

AU - Stutzman-Rodriguez, Kathryn

AU - Chan, Cathy C.

AU - Tasker, Séverine

AU - Lappin, Michael R.

AU - VandeWoude, Sue

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AB - Felis catus gammaherpesvirus 1 (FcaGHV1), recently discovered in the USA, was detected in domestic cats in Australia (11.4%, 95% confidence interval 5.9-19.1, n=110) and Singapore (9.6%, 95% confidence interval 5.9-14.6, n=176) using qPCR. FcaGHV1 qPCR positive cats were 2.8 times more likely to be sick than healthy. Risk factors for FcaGHV1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (FIV) or feline leukaemia virus. FcaGHV1 DNA was detected in multiple tissues from infected cats with consistently high virus loads in the small intestine. FcaGHV1 viral load was significantly higher in FIV-infected cats compared with matched controls, mimicking increased Epstein-Barr virus loads in human immunodeficiency virus-infected humans. FcaGHV1 is endemic in distant geographic regions and is associated with being sick and with coinfections. Horizontal transmission of FcaGHV1 is supported, with biting being a plausible route. A pathogenic role for FcaGHV1 in domestic cats is supported.

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KW - Feline

KW - Gammaherpesvirus

KW - Molecular epidemiology

KW - Transmission

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Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats

Abstract

Keywords

UN SDGs

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Professor Severine Tasker

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Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats

Abstract

Keywords

UN SDGs

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Professor Severine Tasker

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