Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study

Sarah J Lewis, Luisa Zuccolo, George Davey Smith, John A A Macleod, Santiago Rodriguez, Elizabeth S Draper, Margaret Barrow, Rosa Alati, Kapil Sayal, Susan Ring, Jean Golding, Ron Gray

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

Abstract

Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother's intake but also by genetic variants carried by both the mother and the fetus. Associations between children's cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development.
Original languageEnglish
Pages (from-to)e49407
JournalPLoS ONE
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2012

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