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FGFR2 is required for airway basal cell self-renewal and terminal differentiation

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1600-1606
Number of pages7
JournalDevelopment (Cambridge)
Volume144
Issue number9
DOIs
DateAccepted/In press - 15 Mar 2017
DatePublished (current) - 1 May 2017

Abstract

Airway stem cells slowly self-renew and produce differentiated progeny to maintain homeostasis throughout the lifespan of an individual. Mutations in the molecular regulators of these processes may drive cancer or degenerative disease, but are also potential therapeutic targets. Conditionally deleting one copy of FGF receptor 2 (FGFR2) in adult mouse airway basal cells results in self-renewal and differentiation phenotypes.We show that FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation: SOX2. This heterozygous phenotype illustrates that subtle changes in receptor tyrosine kinase signalling can have significant effects, perhaps providing an explanation for the numerous changes seen in cancer.

    Research areas

  • Cre-Lox, Lung, Mouse, Progenitor, Trachea

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via The Company of Biologists at https://doi.org/10.1242/dev.135681. Please refer to any applicable terms of use of the publisher.

    Final published version, 11 MB, PDF document

    Licence: CC BY

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