Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction

KD Zacharowski, PA Zacharowski, S Reingruber, P Petzelbauer

    Research output: Contribution to journalArticle (Academic Journal)peer-review

    54 Citations (Scopus)

    Abstract

    The occlusion of a coronary artery leads to ischemia of the myocardium, while permanent occlusion results in cell death and myocardial dysfunction. Early restoration of blood flow is the only means to reduce or prevent myocardial necrosis, but - paradoxically - reperfusion itself contributes to injury of the heart. In animal models, this phenomenon is well described, and there are many different unrelated approaches to reduce reperfusion injury. In humans, however, pharmacological interventions have so far failed to reduce myocardial reperfusion injury. We summarize the pathogenesis of reperfusion injury, detailing the role of fibrin(ogen) and its derivatives. Moreover, we introduce a new concept for fibrin derivatives as potential targets for reperfusion therapy.
    Translated title of the contributionFibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction
    Original languageEnglish
    Pages (from-to)469 - 477
    Number of pages9
    JournalJournal of Molecular Medicine
    Volume84 (6)
    DOIs
    Publication statusPublished - Jun 2006

    Bibliographical note

    Publisher: Springer

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