Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment

N S Clayton, A S Wilson, E P Laurent, R P Grose, E P Carter

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

It is becoming increasingly evident that multiple cell types within the tumor work together to drive tumour progression and impact on both the response to therapy and the dissemination of tumour cells throughout the body. Fibroblast growth factor signalling (FGF) is perturbed in a number of tumors, serving to drive tumor cell proliferation and migration, but also has a central role in orchestrating the plethora of cells that comprise the tumor microenvironment. This review focuses on how this family of signalling molecules can influence the interactions between tumor cells and their surrounding environment. Unraveling the complexities of FGF signalling between the distinct cell types of a tumor may identify additional opportunities for FGF-targeted compounds in therapy and could help combat drug resistance. Developmental Dynamics 246:493-501, 2017. © 2017 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)493-501
Number of pages9
JournalDevelopmental Dynamics
Volume246
Issue number7
Early online date18 May 2017
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Animals
  • Fibroblast Growth Factors/physiology
  • Humans
  • Neoplasms/drug therapy
  • Receptor Cross-Talk
  • Signal Transduction

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