First Case of Idiopathic Eosinophilic Meningoencephalitis in a Sheep

Beatriz Vidaña*, T Floyd, C Brena, R Lyle, A Carson, C M Hamilton, M Wessels

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review


A 1.5-year-old ewe was presented with neurological signs that had been observed from about 2 days prior to death. There had been no clinical response to anti-inflammatory and antibiotic treatment. Histopathological examination of the brain revealed a severe and widespread eosinophilic meningoencephalomyelitis of unknown aetiology. Defining histological features included diffuse angiocentric eosinophilic infiltrates in the neuroparenchyma and meninges, neuronal necrosis, astrocytosis, neuropil vacuolation and occasional glial scars. Differential diagnostics for eosinophilic meningoencephalitis were taken into account and investigated by means of special stains, immunohistochemistry, bacteriology and polymerase chain reaction. No pathological changes or ancillary tests were supportive or revealed a specific aetiology for the condition and therefore it was considered idiopathic. Idiopathic meningoencephalitis is a rare disease, mainly described in man and rarely in dogs, with no apparent aetiological cause or potential breed predisposition. To our knowledge this is the first case of idiopathic eosinophilic meningoencephalitis in a sheep and provides a histopathological guideline for prospective comparative pathology studies.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalJournal of Comparative Pathology
Early online date4 Dec 2019
Publication statusPublished - Jan 2020

Bibliographical note

Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.


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