FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization

Felicity E. Stubbs, Benjamin P. Flynn, Becky L. Conway-Campbell*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced ‘chromatin decompaction’ at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the glucocorticoid receptor (GR) dynamically alters chromatin accessibility during acute-phase transcriptional regulation and beyond.

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalTrends in Endocrinology and Metabolism
Volume29
Issue number4
Early online date21 Feb 2018
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • chromatin
  • decompaction
  • glucocorticoid
  • remodelling
  • transcription

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