FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization

Felicity E. Stubbs; Benjamin P. Flynn; Becky L. Conway-Campbell

doi:10.1016/j.tem.2018.02.003

FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization

Felicity E. Stubbs, Benjamin P. Flynn, Becky L. Conway-Campbell^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Abstract

In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced ‘chromatin decompaction’ at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the glucocorticoid receptor (GR) dynamically alters chromatin accessibility during acute-phase transcriptional regulation and beyond.

Original language	English
Pages (from-to)	204-207
Number of pages	4
Journal	Trends in Endocrinology and Metabolism
Volume	29
Issue number	4
Early online date	21 Feb 2018
DOIs	https://doi.org/10.1016/j.tem.2018.02.003
Publication status	Published - 1 Apr 2018

Keywords

chromatin
decompaction
glucocorticoid
remodelling
transcription

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10.1016/j.tem.2018.02.003

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title = "FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization",

abstract = "In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced {\textquoteleft}chromatin decompaction{\textquoteright} at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the glucocorticoid receptor (GR) dynamically alters chromatin accessibility during acute-phase transcriptional regulation and beyond.",

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