Folding scene investigation: membrane proteins

PJ Booth, P Curnow

Research output: Contribution to journalArticle (Academic Journal)peer-review

68 Citations (Scopus)

Abstract

Investigations into protein folding have concentrated on experimentally tractable proteins with the result that membrane protein folding remains unsolved. New evidence is providing insight into the nature of the interactions stabilising the folded state of α-helical membrane proteins as well as giving hints on the character of the folding transition state. These developments show that classical methods used for water-soluble proteins can be successfully adapted for membrane proteins. The advances, coupled with increasing numbers of solved crystal structures, augur well for future research into the mechanisms of membrane protein folding.
Translated title of the contributionFolding scene investigation: membrane proteins
Original languageEnglish
Pages (from-to)8 - 13
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume19 (1)
DOIs
Publication statusPublished - Feb 2009

Bibliographical note

Other: First published online 20th January 2009

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