Force-induced repolarization of an active crawler

Pierre Recho*, Thibaut Putelat, Lev Truskinovsky

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Abstract

We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.
Original languageEnglish
Article number033015
Number of pages10
JournalNew Journal of Physics
Volume21
Issue number3
DOIs
Publication statusPublished - 19 Mar 2019

Keywords

  • active particle
  • cell crawling, active gel
  • cell oscillations
  • contact inhibition of locomotion
  • force-velocity relations

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