Force-induced repolarization of an active crawler

Pierre Recho; Thibaut Putelat; Lev Truskinovsky

doi:10.1088/1367-2630/ab05fd

Force-induced repolarization of an active crawler

Pierre Recho^*
, Thibaut Putelat
, Lev Truskinovsky

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

Abstract

We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.

Original language	English
Article number	033015
Number of pages	10
Journal	New Journal of Physics
Volume	21
Issue number	3
DOIs	https://doi.org/10.1088/1367-2630/ab05fd https://doi.org/10.1088/1367-2630/ab05fd
Publication status	Published - 19 Mar 2019

Keywords

active particle
cell crawling, active gel
cell oscillations
contact inhibition of locomotion
force-velocity relations

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10.1088/1367-2630/ab05fdLicence: CC BY
10.1088/1367-2630/ab05fd

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title = "Force-induced repolarization of an active crawler",

abstract = "We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.",

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author = "Pierre Recho and Thibaut Putelat and Lev Truskinovsky",

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T1 - Force-induced repolarization of an active crawler

AU - Recho, Pierre

AU - Putelat, Thibaut

AU - Truskinovsky, Lev

PY - 2019/3/19

Y1 - 2019/3/19

N2 - We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.

AB - We develop a quantitative model of mechanical repolarization in a contraction-driven gel layer mimicking a crawling cell. We show that the force-velocity relations for such active crawlers exhibit multi-valuedness and hysteresis under both force and velocity control. The model predicts steady oscillations of cells attached to an elastic environment and offers a self-consistent mechanical explanation for all experimentally observed outcomes of cell collision tests.

KW - active particle

KW - cell crawling, active gel

KW - cell oscillations

KW - contact inhibition of locomotion

KW - force-velocity relations

UR - https://www.scopus.com/pages/publications/85064892841

U2 - 10.1088/1367-2630/ab05fd

DO - 10.1088/1367-2630/ab05fd

M3 - Article (Academic Journal)

AN - SCOPUS:85064892841

SN - 1367-2630

VL - 21

JO - New Journal of Physics

JF - New Journal of Physics

IS - 3

M1 - 033015

ER -

Force-induced repolarization of an active crawler

Abstract

Keywords

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Mechanical stress as a regulator of cell motility

Mechanics of motility initiation and motility arrest in crawling cells

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