Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo

Chong Chen; Pengcheng Ding; manuela mura; Yanghan Chen; Ye Sun; Lev N. Kantorovich; Henkjan Gersen; Flemming Besenbacher; Miao Yu

doi:10.1002/anie.201808613

Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo

Chong Chen, Pengcheng Ding, manuela mura, Yanghan Chen, Ye Sun, Lev N. Kantorovich, Henkjan Gersen, Flemming Besenbacher, Miao Yu

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

By reacting with NaCl on Au(111), the formation of hypoxanthine (HX) tetrads is demonstrated at the atomic scale in real space. These results directly demonstrate that alternative purine tetrads can be formed in both planar and non-planar configuration, and that ionic bonding plays a crucial role for the formation and planar-to-stereo transformation of the tetrads, providing deeper insight for constructing artificial DNA/RNA quadruplexes. Moreover, both the tilted HXs and Na show strong charge transfer with the substrate in the non-planar phase. The insights gained by this work also open up new routes to tune the electrostatic nature of metal–organic interfaces and design stereo-nanostructures on surfaces.

Original language	English
Pages (from-to)	16015-16019
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	49
Early online date	17 Nov 2018
DOIs	https://doi.org/10.1002/anie.201808613
Publication status	Published - 3 Dec 2018

Keywords

hypoxanthine
tetrad
non-planarity
ionic bonding
Scanning tunneling microscopy

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10.1002/anie.201808613

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201808613 . Please refer to any applicable terms of use of the publisher.
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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201808613 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 622 KBLicence: Unspecified

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Dr Henkjan Gersen
- H.Gersenbristol.acuk
- School of Physics - Honorary Industrial Professor
- Fundamental Bioscience
- The Bristol Centre for Nanoscience and Quantum Information
Person: Member, Honorary and Visiting Academic

Cite this

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title = "Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo",

abstract = "By reacting with NaCl on Au(111), the formation of hypoxanthine (HX) tetrads is demonstrated at the atomic scale in real space. These results directly demonstrate that alternative purine tetrads can be formed in both planar and non-planar configuration, and that ionic bonding plays a crucial role for the formation and planar-to-stereo transformation of the tetrads, providing deeper insight for constructing artificial DNA/RNA quadruplexes. Moreover, both the tilted HXs and Na show strong charge transfer with the substrate in the non-planar phase. The insights gained by this work also open up new routes to tune the electrostatic nature of metal–organic interfaces and design stereo-nanostructures on surfaces.",

keywords = "hypoxanthine, tetrad, non-planarity, ionic bonding, Scanning tunneling microscopy",

author = "Chong Chen and Pengcheng Ding and manuela mura and Yanghan Chen and Ye Sun and Kantorovich, {Lev N.} and Henkjan Gersen and Flemming Besenbacher and Miao Yu",

year = "2018",

month = dec,

day = "3",

doi = "10.1002/anie.201808613",

language = "English",

volume = "57",

pages = "16015--16019",

journal = "Angewandte Chemie - International Edition",

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TY - JOUR

T1 - Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride

T2 - From Planar to Stereo

AU - Chen, Chong

AU - Ding, Pengcheng

AU - mura, manuela

AU - Chen, Yanghan

AU - Sun, Ye

AU - Kantorovich, Lev N.

AU - Gersen, Henkjan

AU - Besenbacher, Flemming

AU - Yu, Miao

PY - 2018/12/3

Y1 - 2018/12/3

N2 - By reacting with NaCl on Au(111), the formation of hypoxanthine (HX) tetrads is demonstrated at the atomic scale in real space. These results directly demonstrate that alternative purine tetrads can be formed in both planar and non-planar configuration, and that ionic bonding plays a crucial role for the formation and planar-to-stereo transformation of the tetrads, providing deeper insight for constructing artificial DNA/RNA quadruplexes. Moreover, both the tilted HXs and Na show strong charge transfer with the substrate in the non-planar phase. The insights gained by this work also open up new routes to tune the electrostatic nature of metal–organic interfaces and design stereo-nanostructures on surfaces.

AB - By reacting with NaCl on Au(111), the formation of hypoxanthine (HX) tetrads is demonstrated at the atomic scale in real space. These results directly demonstrate that alternative purine tetrads can be formed in both planar and non-planar configuration, and that ionic bonding plays a crucial role for the formation and planar-to-stereo transformation of the tetrads, providing deeper insight for constructing artificial DNA/RNA quadruplexes. Moreover, both the tilted HXs and Na show strong charge transfer with the substrate in the non-planar phase. The insights gained by this work also open up new routes to tune the electrostatic nature of metal–organic interfaces and design stereo-nanostructures on surfaces.

KW - hypoxanthine

KW - tetrad

KW - non-planarity

KW - ionic bonding

KW - Scanning tunneling microscopy

U2 - 10.1002/anie.201808613

DO - 10.1002/anie.201808613

M3 - Article (Academic Journal)

C2 - 30334357

VL - 57

SP - 16015

EP - 16019

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 49

ER -

Formation of Hypoxanthine Tetrad by Reaction with Sodium Chloride: From Planar to Stereo

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Keywords

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