Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs

Duncan R. Casey; Sarra C. Sebai; Gemma C. Shearman; Oscar Ces; Robert V. Law; Richard H. Templer; Antony D. Gee

doi:10.1021/ie071265q

Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs

Duncan R. Casey, Sarra C. Sebai, Gemma C. Shearman, Oscar Ces, Robert V. Law, Richard H. Templer^*, Antony D. Gee

^*Corresponding author for this work

School of Physics

Research output: Contribution to journal › Article (Academic Journal) › peer-review

9 Citations (Scopus)

Abstract

Cationic amphiphilic drugs (CADs), such as haloperidol, are able to translocate through biological membrane bilayers via a chemically activated degradation of the phospholipid fabric of the membrane, which may constitute a third type of drug translocation process. We present evidence that this effect is dependent on the drug formulation. The choice of drug counterion is shown to influence the rate of bilayer hydrolysis, leading either to promotion of the reaction or the drug's precipitation via a counterion condensation process.

Original language	English
Pages (from-to)	650-655
Number of pages	6
Journal	Industrial and Engineering Chemistry Research
Volume	47
Issue number	3
DOIs	https://doi.org/10.1021/ie071265q
Publication status	Published - 6 Feb 2008

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title = "Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs",

abstract = "Cationic amphiphilic drugs (CADs), such as haloperidol, are able to translocate through biological membrane bilayers via a chemically activated degradation of the phospholipid fabric of the membrane, which may constitute a third type of drug translocation process. We present evidence that this effect is dependent on the drug formulation. The choice of drug counterion is shown to influence the rate of bilayer hydrolysis, leading either to promotion of the reaction or the drug's precipitation via a counterion condensation process.",

author = "Casey, {Duncan R.} and Sebai, {Sarra C.} and Shearman, {Gemma C.} and Oscar Ces and Law, {Robert V.} and Templer, {Richard H.} and Gee, {Antony D.}",

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T1 - Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs

AU - Casey, Duncan R.

AU - Sebai, Sarra C.

AU - Shearman, Gemma C.

AU - Ces, Oscar

AU - Law, Robert V.

AU - Templer, Richard H.

AU - Gee, Antony D.

PY - 2008/2/6

Y1 - 2008/2/6

N2 - Cationic amphiphilic drugs (CADs), such as haloperidol, are able to translocate through biological membrane bilayers via a chemically activated degradation of the phospholipid fabric of the membrane, which may constitute a third type of drug translocation process. We present evidence that this effect is dependent on the drug formulation. The choice of drug counterion is shown to influence the rate of bilayer hydrolysis, leading either to promotion of the reaction or the drug's precipitation via a counterion condensation process.

AB - Cationic amphiphilic drugs (CADs), such as haloperidol, are able to translocate through biological membrane bilayers via a chemically activated degradation of the phospholipid fabric of the membrane, which may constitute a third type of drug translocation process. We present evidence that this effect is dependent on the drug formulation. The choice of drug counterion is shown to influence the rate of bilayer hydrolysis, leading either to promotion of the reaction or the drug's precipitation via a counterion condensation process.

UR - http://www.scopus.com/inward/record.url?scp=39449106650&partnerID=8YFLogxK

U2 - 10.1021/ie071265q

DO - 10.1021/ie071265q

M3 - Article (Academic Journal)

AN - SCOPUS:39449106650

SN - 0888-5885

VL - 47

SP - 650

EP - 655

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

IS - 3

ER -

Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs

Abstract

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