Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs

Duncan R. Casey, Sarra C. Sebai, Gemma C. Shearman, Oscar Ces, Robert V. Law, Richard H. Templer*, Antony D. Gee

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Abstract

Cationic amphiphilic drugs (CADs), such as haloperidol, are able to translocate through biological membrane bilayers via a chemically activated degradation of the phospholipid fabric of the membrane, which may constitute a third type of drug translocation process. We present evidence that this effect is dependent on the drug formulation. The choice of drug counterion is shown to influence the rate of bilayer hydrolysis, leading either to promotion of the reaction or the drug's precipitation via a counterion condensation process.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalIndustrial and Engineering Chemistry Research
Volume47
Issue number3
DOIs
Publication statusPublished - 6 Feb 2008

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