FoxP influences the speed and accuracy of a perceptual decision in Drosophila

Shamik DasGupta, Clara Howcroft Ferreira, Gero Miesenböck

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Decisions take time if information gradually accumulates to a response threshold, but the neural mechanisms of integration and thresholding are unknown. We characterized a decision process in Drosophila that bears the behavioral signature of evidence accumulation. As stimulus contrast in trained odor discriminations decreased, reaction times increased and perceptual accuracy declined, in quantitative agreement with a drift-diffusion model. FoxP mutants took longer than wild-type flies to form decisions of similar or reduced accuracy, especially in difficult, low-contrast tasks. RNA interference with FoxP expression in αβ core Kenyon cells, or the overexpression of a potassium conductance in these neurons, recapitulated the FoxP mutant phenotype. A mushroom body subdomain whose development or function require the transcription factor FoxP thus supports the progression of a decision toward commitment.

Original languageEnglish
Pages (from-to)901-904
Number of pages4
JournalScience
Volume344
Issue number6186
DOIs
Publication statusPublished - 23 May 2014

Bibliographical note

Copyright © 2014, American Association for the Advancement of Science.

Keywords

  • Animals
  • Behavior, Animal
  • Cell Line
  • Decision Making
  • Drosophila Proteins/genetics
  • Drosophila melanogaster/genetics
  • Forkhead Transcription Factors/genetics
  • Mushroom Bodies/growth & development
  • Mutation
  • Neurons/physiology
  • Odorants
  • Psychomotor Performance
  • RNA Interference
  • Reaction Time/genetics
  • Smell

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