Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

Ralf J P van der Valk, Liesbeth Duijts, Nicholas John Timpson, Muhammad T Salam, Marie Standl, John A Curtin, Jon Genuneit, Marjan Kerhof, Eskil Kreiner-Møller, Alejandro Cáceres, Anna Gref, Liming L Liang, H Rob Taal, Emmanuelle Bouzigon, Florence Demenais, Rachel Nadif, Carole Ober, Emma E Thompson, Karol Estrada, Albert HofmanAndré G Uitterlinden, Cornélia van Duijn, Fernando Rivadeneira, Xia Li, Sandrah P Eckel, Kiros Berhane, W James Gauderman, Raquel Granell, David M Evans, Beate St Pourcain, Wendy McArdle, John P Kemp, George Davey Smith, Carla M T Tiesler, Claudia Flexeder, Angela Simpson, Clare S Murray, Oliver Fuchs, Dirkje S Postma, Klaus Bønnelykke, Maties Torrent, Martin Andersson, Patrick Sleiman, Hakon Hakonarson, William O Cookson, Miriam F Moffatt, Lavinia Paternoster, Erik Melén, Jordi Sunyer, Hans Bisgaard, for the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Abstract

The fraction of exhaled nitric oxide (Feno) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma. Identification of common genetic variants associated with childhood Feno values might help to define biological mechanisms related to specific asthma phenotypes.
Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
DOIs
Publication statusPublished - 5 Dec 2013

Bibliographical note

Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

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  • Projects

    MRC UoB UNITE Unit - programme 3

    Timpson, N. J. & Timpson, N. J.

    1/06/1331/03/18

    Project: Research

    MRC UoB UNITE Unit - Programme 1

    Davey Smith, G.

    1/06/1331/03/18

    Project: Research

    Activities

    • 1 Advisory work for/on national or international committee or working group

    EAGLE/EGG (External organisation)

    M U B St Pourcain (Member)

    2010 → …

    Activity: Membership typesAdvisory work for/on national or international committee or working group

    Cite this

    van der Valk, R. J. P., Duijts, L., Timpson, N. J., Salam, M. T., Standl, M., Curtin, J. A., Genuneit, J., Kerhof, M., Kreiner-Møller, E., Cáceres, A., Gref, A., Liang, L. L., Taal, H. R., Bouzigon, E., Demenais, F., Nadif, R., Ober, C., Thompson, E. E., Estrada, K., ... for the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (2013). Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2013.08.053