From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"

Hector A Cabrera-Fuentes, Julian Aragones, Jürgen Bernhagen, Andreas Boening, William A Boisvert, Hans E Bøtker, Heerajnarain Bulluck, Stuart Cook, Fabio Di Lisa, Felix B Engel, Bernd Engelmann, Fulvia Ferrazzi, Péter Ferdinandy, Alan Fong, Ingrid Fleming, Erich Gnaiger, Sauri Hernández-Reséndiz, Siavash Beikoghli Kalkhoran, Moo Hyun Kim, Sandrine LecourElisa A Liehn, Michael S Marber, Manuel Mayr, Tetsuji Miura, Sang-Bing Ong, Karlheinz Peter, Daniel Sedding, Manvendra K Singh, M.Saadeh Suleiman, Hans J Schnittler, Rainer Schulz, Winston Shim, Daniel Tello, Carl-Wilhelm Vogel, Malcolm Walker, Qilong Oscar Yang Li, Derek M Yellon, Derek J Hausenloy, Klaus T Preissner

Research output: Contribution to journalArticle (Academic Journal)peer-review

32 Citations (Scopus)
249 Downloads (Pure)

Abstract

In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.

Original languageEnglish
Pages (from-to)69-81
Number of pages13
JournalBasic Research in Cardiology
Volume111
Issue number6
Early online date14 Oct 2016
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Cardiomyocyte signaling pathways
  • Cardioprotection
  • Cardiovascular disease
  • Comorbidities
  • Drug targeting
  • Endothelial permeability
  • Extracellular RNA (eRNA) H
  • Heart regeneration
  • Induced pluripotent stem cells
  • Ischemia–reperfusion injury
  • Lipid metabolism
  • MicroRNAs (miRNAs)
  • Mitochondria
  • Remote ischemic conditioning

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