TY - JOUR
T1 - From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics
T2 - meeting report from the third international symposium on "New frontiers in cardiovascular research"
AU - Cabrera-Fuentes, Hector A
AU - Aragones, Julian
AU - Bernhagen, Jürgen
AU - Boening, Andreas
AU - Boisvert, William A
AU - Bøtker, Hans E
AU - Bulluck, Heerajnarain
AU - Cook, Stuart
AU - Di Lisa, Fabio
AU - Engel, Felix B
AU - Engelmann, Bernd
AU - Ferrazzi, Fulvia
AU - Ferdinandy, Péter
AU - Fong, Alan
AU - Fleming, Ingrid
AU - Gnaiger, Erich
AU - Hernández-Reséndiz, Sauri
AU - Kalkhoran, Siavash Beikoghli
AU - Kim, Moo Hyun
AU - Lecour, Sandrine
AU - Liehn, Elisa A
AU - Marber, Michael S
AU - Mayr, Manuel
AU - Miura, Tetsuji
AU - Ong, Sang-Bing
AU - Peter, Karlheinz
AU - Sedding, Daniel
AU - Singh, Manvendra K
AU - Suleiman, M.Saadeh
AU - Schnittler, Hans J
AU - Schulz, Rainer
AU - Shim, Winston
AU - Tello, Daniel
AU - Vogel, Carl-Wilhelm
AU - Walker, Malcolm
AU - Li, Qilong Oscar Yang
AU - Yellon, Derek M
AU - Hausenloy, Derek J
AU - Preissner, Klaus T
PY - 2016/11/1
Y1 - 2016/11/1
N2 - In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.
AB - In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.
KW - Cardiomyocyte signaling pathways
KW - Cardioprotection
KW - Cardiovascular disease
KW - Comorbidities
KW - Drug targeting
KW - Endothelial permeability
KW - Extracellular RNA (eRNA) H
KW - Heart regeneration
KW - Induced pluripotent stem cells
KW - Ischemia–reperfusion injury
KW - Lipid metabolism
KW - MicroRNAs (miRNAs)
KW - Mitochondria
KW - Remote ischemic conditioning
U2 - 10.1007/s00395-016-0586-x
DO - 10.1007/s00395-016-0586-x
M3 - Article (Academic Journal)
C2 - 27743118
SN - 0300-8428
VL - 111
SP - 69
EP - 81
JO - Basic Research in Cardiology
JF - Basic Research in Cardiology
IS - 6
ER -
