From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"

Hector A Cabrera-Fuentes; Julian Aragones; Jürgen Bernhagen; Andreas Boening; William A Boisvert; Hans E Bøtker; Heerajnarain Bulluck; Stuart Cook; Fabio Di Lisa; Felix B Engel; Bernd Engelmann; Fulvia Ferrazzi; Péter Ferdinandy; Alan Fong; Ingrid Fleming; Erich Gnaiger; Sauri Hernández-Reséndiz; Siavash Beikoghli Kalkhoran; Moo Hyun Kim; Sandrine Lecour; Elisa A Liehn; Michael S Marber; Manuel Mayr; Tetsuji Miura; Sang-Bing Ong; Karlheinz Peter; Daniel Sedding; Manvendra K Singh; M.Saadeh Suleiman; Hans J Schnittler; Rainer Schulz; Winston Shim; Daniel Tello; Carl-Wilhelm Vogel; Malcolm Walker; Qilong Oscar Yang Li; Derek M Yellon; Derek J Hausenloy; Klaus T Preissner

doi:10.1007/s00395-016-0586-x

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"

Hector A Cabrera-Fuentes
, Julian Aragones
, Jürgen Bernhagen
, Andreas Boening
, William A Boisvert
, Hans E Bøtker
, Heerajnarain Bulluck
, Stuart Cook
, Fabio Di Lisa
, Felix B Engel
, Bernd Engelmann
, Fulvia Ferrazzi
, Péter Ferdinandy
, Alan Fong
, Ingrid Fleming
, Erich Gnaiger
, Sauri Hernández-Reséndiz
, Siavash Beikoghli Kalkhoran
, Moo Hyun Kim
, Sandrine Lecour

Elisa A Liehn, Michael S Marber, Manuel Mayr, Tetsuji Miura, Sang-Bing Ong, Karlheinz Peter, Daniel Sedding, Manvendra K Singh, M.Saadeh Suleiman, Hans J Schnittler, Rainer Schulz, Winston Shim, Daniel Tello, Carl-Wilhelm Vogel, Malcolm Walker, Qilong Oscar Yang Li, Derek M Yellon, Derek J Hausenloy, Klaus T Preissner

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

47 Citations (Scopus)

342 Downloads (Pure)

Abstract

In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.

Original language	English
Pages (from-to)	69-81
Number of pages	13
Journal	Basic Research in Cardiology
Volume	111
Issue number	6
Early online date	14 Oct 2016
DOIs	https://doi.org/10.1007/s00395-016-0586-x
Publication status	Published - 1 Nov 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardiomyocyte signaling pathways
Cardioprotection
Cardiovascular disease
Comorbidities
Drug targeting
Endothelial permeability
Extracellular RNA (eRNA) H
Heart regeneration
Induced pluripotent stem cells
Ischemia–reperfusion injury
Lipid metabolism
MicroRNAs (miRNAs)
Mitochondria
Remote ischemic conditioning

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10.1007/s00395-016-0586-x

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Cabrera-Fuentes, H. A., Aragones, J., Bernhagen, J., Boening, A., Boisvert, W. A., Bøtker, H. E., Bulluck, H., Cook, S., Di Lisa, F., Engel, F. B., Engelmann, B., Ferrazzi, F., Ferdinandy, P., Fong, A., Fleming, I., Gnaiger, E., Hernández-Reséndiz, S., Kalkhoran, S. B., Kim, M. H., ... Preissner, K. T. (2016). From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Research in Cardiology, 111(6), 69-81. https://doi.org/10.1007/s00395-016-0586-x

Cabrera-Fuentes, Hector A ; Aragones, Julian ; Bernhagen, Jürgen et al. / From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics : meeting report from the third international symposium on "New frontiers in cardiovascular research". In: Basic Research in Cardiology. 2016 ; Vol. 111, No. 6. pp. 69-81.

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abstract = "In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.",

keywords = "Cardiomyocyte signaling pathways, Cardioprotection, Cardiovascular disease , Comorbidities, Drug targeting, Endothelial permeability, Extracellular RNA (eRNA) H, Heart regeneration, Induced pluripotent stem cells, Ischemia–reperfusion injury, Lipid metabolism, MicroRNAs (miRNAs), Mitochondria, Remote ischemic conditioning",

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Cabrera-Fuentes, HA, Aragones, J, Bernhagen, J, Boening, A, Boisvert, WA, Bøtker, HE, Bulluck, H, Cook, S, Di Lisa, F, Engel, FB, Engelmann, B, Ferrazzi, F, Ferdinandy, P, Fong, A, Fleming, I, Gnaiger, E, Hernández-Reséndiz, S, Kalkhoran, SB, Kim, MH, Lecour, S, Liehn, EA, Marber, MS, Mayr, M, Miura, T, Ong, S-B, Peter, K, Sedding, D, Singh, MK, Suleiman, MS, Schnittler, HJ, Schulz, R, Shim, W, Tello, D, Vogel, C-W, Walker, M, Li, QOY, Yellon, DM, Hausenloy, DJ & Preissner, KT 2016, 'From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"', Basic Research in Cardiology, vol. 111, no. 6, pp. 69-81. https://doi.org/10.1007/s00395-016-0586-x

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". / Cabrera-Fuentes, Hector A; Aragones, Julian; Bernhagen, Jürgen et al.
In: Basic Research in Cardiology, Vol. 111, No. 6, 01.11.2016, p. 69-81.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics

T2 - meeting report from the third international symposium on "New frontiers in cardiovascular research"

AU - Cabrera-Fuentes, Hector A

AU - Aragones, Julian

AU - Bernhagen, Jürgen

AU - Boening, Andreas

AU - Boisvert, William A

AU - Bøtker, Hans E

AU - Bulluck, Heerajnarain

AU - Cook, Stuart

AU - Di Lisa, Fabio

AU - Engel, Felix B

AU - Engelmann, Bernd

AU - Ferrazzi, Fulvia

AU - Ferdinandy, Péter

AU - Fong, Alan

AU - Fleming, Ingrid

AU - Gnaiger, Erich

AU - Hernández-Reséndiz, Sauri

AU - Kalkhoran, Siavash Beikoghli

AU - Kim, Moo Hyun

AU - Lecour, Sandrine

AU - Liehn, Elisa A

AU - Marber, Michael S

AU - Mayr, Manuel

AU - Miura, Tetsuji

AU - Ong, Sang-Bing

AU - Peter, Karlheinz

AU - Sedding, Daniel

AU - Singh, Manvendra K

AU - Suleiman, M.Saadeh

AU - Schnittler, Hans J

AU - Schulz, Rainer

AU - Shim, Winston

AU - Tello, Daniel

AU - Vogel, Carl-Wilhelm

AU - Walker, Malcolm

AU - Li, Qilong Oscar Yang

AU - Yellon, Derek M

AU - Hausenloy, Derek J

AU - Preissner, Klaus T

PY - 2016/11/1

Y1 - 2016/11/1

N2 - In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.

AB - In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients' cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune reactions in cardioprotection. Moreover, developmental or systems biology approaches bear great potential in systematically uncovering unexpected components involved in ischemia-reperfusion injury or heart regeneration. Based on the characterization of particular platelet integrins, mitochondrial redox-linked proteins, or lipid-diol compounds in cardiovascular diseases, their targeting by newly developed theranostics and technologies opens new avenues for diagnosis and therapy of myocardial infarction to improve the patients' outcome.

KW - Cardiomyocyte signaling pathways

KW - Cardioprotection

KW - Cardiovascular disease

KW - Comorbidities

KW - Drug targeting

KW - Endothelial permeability

KW - Extracellular RNA (eRNA) H

KW - Heart regeneration

KW - Induced pluripotent stem cells

KW - Ischemia–reperfusion injury

KW - Lipid metabolism

KW - MicroRNAs (miRNAs)

KW - Mitochondria

KW - Remote ischemic conditioning

U2 - 10.1007/s00395-016-0586-x

DO - 10.1007/s00395-016-0586-x

M3 - Article (Academic Journal)

C2 - 27743118

SN - 0300-8428

VL - 111

SP - 69

EP - 81

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

IS - 6

ER -

Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE et al. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Research in Cardiology. 2016 Nov 1;111(6):69-81. Epub 2016 Oct 14. doi: 10.1007/s00395-016-0586-x