From Eggs to Hearts: What Is the Link between Cyclic ADP-Ribose and Ryanodine Receptors?

E Venturi, S Pitt, E Galfré, R Sitsapesan

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)

Abstract

It was first proposed that cyclic ADP-ribose (cADPR) could activate ryanodine receptors (RyR) in 1991. Following a subsequent report that cADPR could activate cardiac RyR (RyR2) reconstituted into artificial membranes and stimulate Ca(2+) -release from isolated cardiac SR, there has been a steadily mounting stockpile of publications proclaiming the physiological and pathophysiological importance of cADPR in the cardiovascular system. It was only 2 years earlier, in 1989, that cADPR was first identified as the active metabolite of nicotinamide adenine dinucleotide (NAD), responsible for triggering the release of Ca(2+) from crude homogenates of sea urchin eggs. Twenty years later, can we boast of being any closer to unraveling the mechanisms by which cADPR modulates intracellular Ca(2+) -release? This review sets out to examine the mechanisms underlying the effects of cADPR and ask whether cADPR is an important signaling molecule in the heart.
Translated title of the contributionFrom Eggs to Hearts: What Is the Link between Cyclic ADP-Ribose and Ryanodine Receptors?
Original languageEnglish
JournalCardiovascular Therapeutics
DOIs
Publication statusPublished - 2010

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