From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Nicholas K Priest; Justine K Rudkin; Edward J Feil; Jean M H van den Elsen; Ambrose Cheung; Sharon J Peacock; Maisem Laabei; David A Lucks; Mario Recker; Ruth C Massey

doi:10.1038/nrmicro2880

From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Nicholas K Priest, Justine K Rudkin, Edward J Feil, Jean M H van den Elsen, Ambrose Cheung, Sharon J Peacock, Maisem Laabei, David A Lucks, Mario Recker, Ruth C Massey

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

61 Citations (Scopus)

Abstract

With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.

Original language	English
Pages (from-to)	791-7
Number of pages	7
Journal	Nature Reviews Microbiology
Volume	10
Issue number	11
DOIs	https://doi.org/10.1038/nrmicro2880
Publication status	Published - Nov 2012

Keywords

DNA, Bacterial/genetics
Genetic Variation
Genome, Bacterial
Genotype
Humans
Methicillin Resistance/genetics
Phenotype
Staphylococcal Infections/microbiology
Staphylococcus aureus/genetics
Systems Biology/methods
Virulence Factors/genetics

Access to Document

10.1038/nrmicro2880

Handle.net

Persistent link

Cite this

@article{3987084c77134c6a8ddf4e6198259b0a,

title = "From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?",

abstract = "With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.",

keywords = "DNA, Bacterial/genetics, Genetic Variation, Genome, Bacterial, Genotype, Humans, Methicillin Resistance/genetics, Phenotype, Staphylococcal Infections/microbiology, Staphylococcus aureus/genetics, Systems Biology/methods, Virulence Factors/genetics",

author = "Priest, {Nicholas K} and Rudkin, {Justine K} and Feil, {Edward J} and {van den Elsen}, {Jean M H} and Ambrose Cheung and Peacock, {Sharon J} and Maisem Laabei and Lucks, {David A} and Mario Recker and Massey, {Ruth C}",

year = "2012",

month = nov,

doi = "10.1038/nrmicro2880",

language = "English",

volume = "10",

pages = "791--7",

journal = "Nature Reviews Microbiology",

issn = "1740-1526",

publisher = "Springer Nature",

number = "11",

}

TY - JOUR

T1 - From genotype to phenotype

T2 - can systems biology be used to predict Staphylococcus aureus virulence?

AU - Priest, Nicholas K

AU - Rudkin, Justine K

AU - Feil, Edward J

AU - van den Elsen, Jean M H

AU - Cheung, Ambrose

AU - Peacock, Sharon J

AU - Laabei, Maisem

AU - Lucks, David A

AU - Recker, Mario

AU - Massey, Ruth C

PY - 2012/11

Y1 - 2012/11

N2 - With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.

AB - With the advent of high-throughput whole-genome sequencing, it is now possible to sequence a bacterial genome in a matter of hours. However, although the presence or absence of a particular gene can be determined, we do not yet have the tools to extract information about the true virulence potential of an organism from sequence data alone. Here, we focus on the important human pathogen Staphylococcus aureus and present a framework for the construction of a broad systems biology-based tool that could be used to predict virulence phenotypes from S. aureus genomic sequences using existing technology.

KW - DNA, Bacterial/genetics

KW - Genetic Variation

KW - Genome, Bacterial

KW - Genotype

KW - Humans

KW - Methicillin Resistance/genetics

KW - Phenotype

KW - Staphylococcal Infections/microbiology

KW - Staphylococcus aureus/genetics

KW - Systems Biology/methods

KW - Virulence Factors/genetics

U2 - 10.1038/nrmicro2880

DO - 10.1038/nrmicro2880

M3 - Review article (Academic Journal)

C2 - 23070558

SN - 1740-1526

VL - 10

SP - 791

EP - 797

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 11

ER -

From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this