From observational to dynamic genetics

Claire M A Haworth*, Oliver S P Davis

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)


Twin and family studies have shown that most traits are at least moderately heritable. But what are the implications of finding genetic influence for the design of intervention and prevention programs? For complex traits, heritability does not mean immutability, and research has shown that genetic influences can change with age, context, and in response to behavioral and drug interventions. The most significant implications for intervention will come when we move from observational genetics to investigating dynamic genetics, including genetically sensitive interventions. Future interventions should be designed to overcome genetic risk and draw upon genetic strengths by changing the environment.

Original languageEnglish
Article numberArticle 6
JournalFrontiers in Genetics
Issue numberJAN
Publication statusPublished - 1 Jan 2014


  • Dynamic genetics
  • Gene-environment interaction
  • Heritability
  • Intervention
  • Twins


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