Functional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release

SE Lauri, A Vesikansa, M Segerstråle, GL Collingridge, JTR Isaac, T Taira

Research output: Contribution to journalArticle (Academic Journal)peer-review

101 Citations (Scopus)

Abstract

Early in development, excitatory synapses transmit with low efficacy, one mechanism for which is a low probability of transmitter release (Pr). However, little is known about the developmental mechanisms that control activity-dependent maturation of the presynaptic release. Here, we show that during early development, transmission at CA3-CA1 synapses is regulated by a high-affinity, G protein-dependent kainate receptor (KAR), which is endogenously activated by ambient glutamate. By tonically depressing glutamate release, this mechanism sets the dynamic properties of neonatal inputs to favor transmission during high frequency bursts of activity, typical for developing neuronal networks. In response to induction of LTP, the tonic activation of KAR is rapidly down regulated, causing an increase in Pr and profoundly changing the dynamic properties of transmission. Early development of the glutamatergic connectivity thus involves an activity-dependent loss of presynaptic KAR function producing maturation in the mode of excitatory transmission from CA3 to CA1.
Translated title of the contributionFunctional maturation of CA1 synapses involves activity-dependent loss of tonic kainate receptor-mediated inhibition of glutamate release
Original languageEnglish
Pages (from-to)415 - 429
Number of pages15
JournalNeuron
Volume50 (3)
DOIs
Publication statusPublished - May 2006

Bibliographical note

Publisher: Elsevier

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