Functions of the Drosophila JAK-STAT pathway: Lessons from stem cells

Marc Amoyel, Erika A Bach

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

JAK-STAT signaling has been proposed to act in numerous stem cells in a variety of organisms. Here we provide an overview of its roles in three well characterized stem cell populations in Drosophila, in the intestine, lymph gland and testis. In flies, there is a single JAK and a single STAT, which has made the genetic dissection of pathway function considerably easier and facilitated the analysis of communication between stem cells, their niches and offspring. Studies in flies have revealed roles for this pathway as diverse as regulating bona fide intrinsic self-renewal, integrating response to environmental cues that control quiescence and promoting mitogenic responses to stress.

Original languageEnglish
Pages (from-to)176-83
Number of pages8
JournalJAK-STAT
Volume1
Issue number3
DOIs
Publication statusPublished - 1 Jul 2012

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