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Fundamental differences in patterns of retinal ageing between primates and mice

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Fundamental differences in patterns of retinal ageing between primates and mice. / Kam, Jaimie Hoh; Weinrich, Tobias W.; Shinhmar, Harpreet; Powner, Michael B.; Roberts, Nicholas W.; Aboelnour, Asmaa; Jeffery, Glen.

In: Scientific Reports, Vol. 9, 12574 (2019), 29.08.2019.

Research output: Contribution to journalArticle

Harvard

Kam, JH, Weinrich, TW, Shinhmar, H, Powner, MB, Roberts, NW, Aboelnour, A & Jeffery, G 2019, 'Fundamental differences in patterns of retinal ageing between primates and mice', Scientific Reports, vol. 9, 12574 (2019). https://doi.org/10.1038/s41598-019-49121-0

APA

Kam, J. H., Weinrich, T. W., Shinhmar, H., Powner, M. B., Roberts, N. W., Aboelnour, A., & Jeffery, G. (2019). Fundamental differences in patterns of retinal ageing between primates and mice. Scientific Reports, 9, [12574 (2019)]. https://doi.org/10.1038/s41598-019-49121-0

Vancouver

Kam JH, Weinrich TW, Shinhmar H, Powner MB, Roberts NW, Aboelnour A et al. Fundamental differences in patterns of retinal ageing between primates and mice. Scientific Reports. 2019 Aug 29;9. 12574 (2019). https://doi.org/10.1038/s41598-019-49121-0

Author

Kam, Jaimie Hoh ; Weinrich, Tobias W. ; Shinhmar, Harpreet ; Powner, Michael B. ; Roberts, Nicholas W. ; Aboelnour, Asmaa ; Jeffery, Glen. / Fundamental differences in patterns of retinal ageing between primates and mice. In: Scientific Reports. 2019 ; Vol. 9.

Bibtex

@article{ddcf5edfbd5a4e5b8115767483987e25,
title = "Fundamental differences in patterns of retinal ageing between primates and mice",
abstract = "Photoreceptors have high metabolic demands and age rapidly, undermining visual function. We base our understanding mainly on ageing mice where elevated inflammation, extracellular deposition, including that of amyloid beta, and rod and cone photoreceptor loss occur, but cones are not lost in ageing primate although their function declines, revealing that primate and mouse age differently. We examine ageing primate retinae and show elevated stress but low inflammation. However, aged primates have a >70{\%} reduction in adenosine triphosphate (ATP) and a decrease in cytochrome c oxidase. There is a shift in cone mitochondrial positioning and glycolytic activity increases. Bruch’s membrane thickens but unlike in mice, amyloid beta is absent. Hence, reduced ATP may explain cone functional decline in ageing but their retained presence offers the possibility of functional restoration if they can be fuelled appropriately to restore cellular function. This is important because as humans we largely depend on cone function to see and are rarely fully dark adapted. Presence of limited aged inflammation and amyloid beta deposition question some of the therapeutic approaches taken to resolve problems of retinal ageing in humans and the possible lack of success in clinical trials in macular degeneration that have targeted inflammatory agents.",
keywords = "Experimental models of disease, Retina",
author = "Kam, {Jaimie Hoh} and Weinrich, {Tobias W.} and Harpreet Shinhmar and Powner, {Michael B.} and Roberts, {Nicholas W.} and Asmaa Aboelnour and Glen Jeffery",
year = "2019",
month = "8",
day = "29",
doi = "10.1038/s41598-019-49121-0",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Springer Nature",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Fundamental differences in patterns of retinal ageing between primates and mice

AU - Kam, Jaimie Hoh

AU - Weinrich, Tobias W.

AU - Shinhmar, Harpreet

AU - Powner, Michael B.

AU - Roberts, Nicholas W.

AU - Aboelnour, Asmaa

AU - Jeffery, Glen

PY - 2019/8/29

Y1 - 2019/8/29

N2 - Photoreceptors have high metabolic demands and age rapidly, undermining visual function. We base our understanding mainly on ageing mice where elevated inflammation, extracellular deposition, including that of amyloid beta, and rod and cone photoreceptor loss occur, but cones are not lost in ageing primate although their function declines, revealing that primate and mouse age differently. We examine ageing primate retinae and show elevated stress but low inflammation. However, aged primates have a >70% reduction in adenosine triphosphate (ATP) and a decrease in cytochrome c oxidase. There is a shift in cone mitochondrial positioning and glycolytic activity increases. Bruch’s membrane thickens but unlike in mice, amyloid beta is absent. Hence, reduced ATP may explain cone functional decline in ageing but their retained presence offers the possibility of functional restoration if they can be fuelled appropriately to restore cellular function. This is important because as humans we largely depend on cone function to see and are rarely fully dark adapted. Presence of limited aged inflammation and amyloid beta deposition question some of the therapeutic approaches taken to resolve problems of retinal ageing in humans and the possible lack of success in clinical trials in macular degeneration that have targeted inflammatory agents.

AB - Photoreceptors have high metabolic demands and age rapidly, undermining visual function. We base our understanding mainly on ageing mice where elevated inflammation, extracellular deposition, including that of amyloid beta, and rod and cone photoreceptor loss occur, but cones are not lost in ageing primate although their function declines, revealing that primate and mouse age differently. We examine ageing primate retinae and show elevated stress but low inflammation. However, aged primates have a >70% reduction in adenosine triphosphate (ATP) and a decrease in cytochrome c oxidase. There is a shift in cone mitochondrial positioning and glycolytic activity increases. Bruch’s membrane thickens but unlike in mice, amyloid beta is absent. Hence, reduced ATP may explain cone functional decline in ageing but their retained presence offers the possibility of functional restoration if they can be fuelled appropriately to restore cellular function. This is important because as humans we largely depend on cone function to see and are rarely fully dark adapted. Presence of limited aged inflammation and amyloid beta deposition question some of the therapeutic approaches taken to resolve problems of retinal ageing in humans and the possible lack of success in clinical trials in macular degeneration that have targeted inflammatory agents.

KW - Experimental models of disease

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=85071743179&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-49121-0

DO - 10.1038/s41598-019-49121-0

M3 - Article

C2 - 31467395

AN - SCOPUS:85071743179

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 12574 (2019)

ER -