Furthering genome design using models and algorithms

Joshua P Rees-Garbutt*, Jake Rightmyer, Jonathan Karr, Claire S Grierson*, Lucia Marucci*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Large-scale in-silico genome designs are on the brink of being engineered in-vivo, offering a potential paradigm shift for cellular research (previous designs relied on fractured available knowledge and in-vivo engineering iteration) by integrating computational design, in-silico models and algorithms, with laboratory construction. However, several challenges remain. If in-vivo engineering is successful, designing genomes can be used to gain new understanding of cellular life, improve the metabolite production process, and reduce the risk of unintended genetic modification and release. Here we review the progress so far. We suggest improvements on recent models and algorithms, illustrate the next steps for integrating computational and laboratory engineering, and offer our opinions on the future of the field.
Original languageEnglish
JournalCurrent Opinion in Systems Biology
Early online date16 Oct 2020
DOIs
Publication statusE-pub ahead of print - 16 Oct 2020

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