Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

James W Marshall, Kate M J De Mattos-Shipley*, Iman Ahmed Youssef A Y A Ghannam, Jonathan C Killen, Colin M Lazarus, Russell Cox, Chris L Willis, Thomas J Simpson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review


Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.
Original languageEnglish
Pages (from-to)182
Number of pages187
JournalOrganic and Biomolecular Chemistry
Issue number19
Publication statusPublished - 22 Oct 2020


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