Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

James W Marshall; Kate M J De Mattos-Shipley; Iman Ahmed Youssef A Y A Ghannam; Jonathan C Killen; Colin M Lazarus; Russell Cox; Chris L Willis; Thomas J Simpson

Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

James W Marshall, Kate M J De Mattos-Shipley^*, Iman Ahmed Youssef A Y A Ghannam, Jonathan C Killen, Colin M Lazarus, Russell Cox, Chris L Willis, Thomas J Simpson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.

Original language	English
Pages (from-to)	182
Number of pages	187
Journal	Organic and Biomolecular Chemistry
Issue number	19
Publication status	Published - 22 Oct 2020

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Organic & Biological
Bristol BioDesign Institute

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@article{1b050b34be4f42b3a663dd023b682b29,

title = "Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari",

abstract = "Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.",

author = "Marshall, \{James W\} and \{De Mattos-Shipley\}, \{Kate M J\} and Ghannam, \{Iman Ahmed Youssef A Y A\} and Killen, \{Jonathan C\} and Lazarus, \{Colin M\} and Russell Cox and Willis, \{Chris L\} and Simpson, \{Thomas J\}",

year = "2020",

month = oct,

day = "22",

language = "English",

pages = "182",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "19",

}

TY - JOUR

T1 - Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

AU - Marshall, James W

AU - De Mattos-Shipley, Kate M J

AU - Ghannam, Iman Ahmed Youssef A Y A

AU - Killen, Jonathan C

AU - Lazarus, Colin M

AU - Cox, Russell

AU - Willis, Chris L

AU - Simpson, Thomas J

PY - 2020/10/22

Y1 - 2020/10/22

N2 - Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.

AB - Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.

M3 - Article (Academic Journal)

SN - 1477-0520

SP - 182

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 19

ER -

Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

Abstract

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