Galanin acts as a trophic factor to the central and peripheral nervous systems

SA Hobson, A Bacon, CR Elliot-Hunt, FE Holmes, NCH Kerr, RJP Pope, PA Vanderplank, D Wynick

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

24 Citations (Scopus)

Abstract

The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury or disease. Over the last 10 years, we have demonstrated that the peptide plays a developmental survival role to subsets of neurons in the peripheral and central nervous systems with resulting phenotypic changes in neuropathic pain and cognition. Galanin also appears to play a trophic role to adult sensory neurons following injury, via activation of GalR2, by stimulating neurite outgrowth. Furthermore, galanin also plays a neuroprotective role to the hippocampus following excitotoxic injury, again mediated by activation of GalR2. Most recently, we have shown that galanin expression is markedly up-regulated in multiple sclerosis (MS) lesions and in the experimental autoimmune encephalomyelitis (EAE) model of MS. Over-expression of galanin in transgenic mice abolishes disease in the EAE model, whilst loss-of-function mutations in galanin or GalR2 increase disease severity. In summary, these studies demonstrate that a GalR2 agonist might have clinical utility in a variety of human diseases that affect the nervous system.
Translated title of the contributionGalanin acts as a trophic factor to the central and peripheral nervous systems
Original languageEnglish
Title of host publicationGalanin
PublisherBirkhäuser Basel
Pages25 - 38
Number of pages16
ISBN (Print)9783034602273
Publication statusPublished - 2010

Publication series

NameEXS
Volume102

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