Galanin-expression and galanin-dependent sensory neurons are not required for itch

Fiona E Holmes, Penny Vanderplank, David Wynick

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

BACKGROUND: Galanin is a key modulator of nociception, and it is also required for the developmental survival of a subset of C-fibre sensory neurons which are critical to the mediation of neuropathic and inflammatory pain. However, the potential modulatory roles played by galanin, or the galanin-dependent neurons, in pruritoceptive mechanisms underlying the sensation of itch have not been investigated.

FINDINGS: Here we report that mice carrying a loss-of-function mutation in the galanin gene (Gal-KO) show no differences in spontaneous behavioural itch responses compared to wild-type (WT) controls. Similarly, the responses to a range of pruritogens are not significantly different between the two genotypes.

CONCLUSIONS: These results suggest that neither galanin expression, nor the galanin-dependent subpopulation of sensory neurons is required for itch-related behaviours.

Original languageEnglish
Pages (from-to)87
JournalMolecular Pain
Volume8
DOIs
Publication statusPublished - 2012

Keywords

  • Animals
  • Galanin
  • Male
  • Mice
  • Mice, Knockout
  • Pain
  • Pruritus
  • Sensory Receptor Cells

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