Gamma-glutamyltransferase and risk of chronic kidney disease: A prospective cohort study

Setor K Kunutsor; Jari A Laukkanen

doi:10.1016/j.cca.2017.08.014

Gamma-glutamyltransferase and risk of chronic kidney disease: A prospective cohort study

Setor K Kunutsor, Jari A Laukkanen

Bristol Medical School (THS)

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Abstract

BACKGROUND: Elevated serum gamma-glutamyltransferase (GGT) activity has been linked with an increased risk of chronic kidney disease (CKD) in Asian populations. We aimed to assess the prospective association of serum GGT with risk of CKD in a Caucasian population.

MATERIALS AND METHODS: We related GGT activity to the incidence of CKD in 2338 men aged 42-61years of the Kuopio Ischemic Heart Disease study with normal kidney function at baseline. Repeat measurements of GGT were used to correct for within-person variability.

RESULTS: During a median follow-up of 25.6years, 221 men developed new-onset CKD. The age-adjusted regression dilution ratio of loge GGT was 0.70 (95% CI: 0.64-0.75). Gamma-glutamyltransferase was log-linearly associated with risk of CKD in age-adjusted analysis. In Cox regression analysis adjusted for age, the hazard ratio (95% CIs) for CKD per standard deviation increase in loge baseline GGT was 1.25 (1.09-1.43) which was attenuated to 1.01 (0.86-1.19) on further adjustment for several confounders.

CONCLUSION: Contrary to previous evidence of an independent association between elevated GGT and increased risk of CKD in Asian populations, initial evidence of an association between GGT and CKD in Caucasian men was confounded by body mass index, lifestyle factors, and lipids.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	Clinica Chimica Acta
Volume	473
DOIs	https://doi.org/10.1016/j.cca.2017.08.014
Publication status	Published - 12 Aug 2017

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via elsevier at http://www.sciencedirect.com/science/article/pii/S0009898117303078?via%3Dihub. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 196 KBLicence: CC BY-NC-ND
Supplementary information PDFAccepted author manuscript, 88.3 KBLicence: CC BY-NC-ND

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title = "Gamma-glutamyltransferase and risk of chronic kidney disease: A prospective cohort study",

abstract = "BACKGROUND: Elevated serum gamma-glutamyltransferase (GGT) activity has been linked with an increased risk of chronic kidney disease (CKD) in Asian populations. We aimed to assess the prospective association of serum GGT with risk of CKD in a Caucasian population.MATERIALS AND METHODS: We related GGT activity to the incidence of CKD in 2338 men aged 42-61years of the Kuopio Ischemic Heart Disease study with normal kidney function at baseline. Repeat measurements of GGT were used to correct for within-person variability.RESULTS: During a median follow-up of 25.6years, 221 men developed new-onset CKD. The age-adjusted regression dilution ratio of loge GGT was 0.70 (95% CI: 0.64-0.75). Gamma-glutamyltransferase was log-linearly associated with risk of CKD in age-adjusted analysis. In Cox regression analysis adjusted for age, the hazard ratio (95% CIs) for CKD per standard deviation increase in loge baseline GGT was 1.25 (1.09-1.43) which was attenuated to 1.01 (0.86-1.19) on further adjustment for several confounders.CONCLUSION: Contrary to previous evidence of an independent association between elevated GGT and increased risk of CKD in Asian populations, initial evidence of an association between GGT and CKD in Caucasian men was confounded by body mass index, lifestyle factors, and lipids.",

keywords = "Journal Article",

author = "Kunutsor, {Setor K} and Laukkanen, {Jari A}",

year = "2017",

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day = "12",

doi = "10.1016/j.cca.2017.08.014",

language = "English",

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journal = "Clinica Chimica Acta",

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TY - JOUR

T1 - Gamma-glutamyltransferase and risk of chronic kidney disease

T2 - A prospective cohort study

AU - Kunutsor, Setor K

AU - Laukkanen, Jari A

PY - 2017/8/12

Y1 - 2017/8/12

N2 - BACKGROUND: Elevated serum gamma-glutamyltransferase (GGT) activity has been linked with an increased risk of chronic kidney disease (CKD) in Asian populations. We aimed to assess the prospective association of serum GGT with risk of CKD in a Caucasian population.MATERIALS AND METHODS: We related GGT activity to the incidence of CKD in 2338 men aged 42-61years of the Kuopio Ischemic Heart Disease study with normal kidney function at baseline. Repeat measurements of GGT were used to correct for within-person variability.RESULTS: During a median follow-up of 25.6years, 221 men developed new-onset CKD. The age-adjusted regression dilution ratio of loge GGT was 0.70 (95% CI: 0.64-0.75). Gamma-glutamyltransferase was log-linearly associated with risk of CKD in age-adjusted analysis. In Cox regression analysis adjusted for age, the hazard ratio (95% CIs) for CKD per standard deviation increase in loge baseline GGT was 1.25 (1.09-1.43) which was attenuated to 1.01 (0.86-1.19) on further adjustment for several confounders.CONCLUSION: Contrary to previous evidence of an independent association between elevated GGT and increased risk of CKD in Asian populations, initial evidence of an association between GGT and CKD in Caucasian men was confounded by body mass index, lifestyle factors, and lipids.

AB - BACKGROUND: Elevated serum gamma-glutamyltransferase (GGT) activity has been linked with an increased risk of chronic kidney disease (CKD) in Asian populations. We aimed to assess the prospective association of serum GGT with risk of CKD in a Caucasian population.MATERIALS AND METHODS: We related GGT activity to the incidence of CKD in 2338 men aged 42-61years of the Kuopio Ischemic Heart Disease study with normal kidney function at baseline. Repeat measurements of GGT were used to correct for within-person variability.RESULTS: During a median follow-up of 25.6years, 221 men developed new-onset CKD. The age-adjusted regression dilution ratio of loge GGT was 0.70 (95% CI: 0.64-0.75). Gamma-glutamyltransferase was log-linearly associated with risk of CKD in age-adjusted analysis. In Cox regression analysis adjusted for age, the hazard ratio (95% CIs) for CKD per standard deviation increase in loge baseline GGT was 1.25 (1.09-1.43) which was attenuated to 1.01 (0.86-1.19) on further adjustment for several confounders.CONCLUSION: Contrary to previous evidence of an independent association between elevated GGT and increased risk of CKD in Asian populations, initial evidence of an association between GGT and CKD in Caucasian men was confounded by body mass index, lifestyle factors, and lipids.

KW - Journal Article

U2 - 10.1016/j.cca.2017.08.014

DO - 10.1016/j.cca.2017.08.014

M3 - Article (Academic Journal)

C2 - 28811239

SN - 0009-8981

VL - 473

SP - 39

EP - 44

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

ER -

Gamma-glutamyltransferase and risk of chronic kidney disease: A prospective cohort study

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