Gamma glutamyltransferase and risk of future dementia in middle-aged to older Finnish men: A new prospective cohort study

Setor K. Kunutsor, Jari A. Laukkanen

Research output: Contribution to journalArticle (Academic Journal)peer-review

22 Citations (Scopus)
320 Downloads (Pure)

Abstract

Introduction: We assessed the association of gamma glutamyltransferase (GGT) with risk of dementia. Methods Serum GGT activity was assessed at baseline in the Kuopio Ischemic Heart Disease prospective cohort of 2415 relatively healthy men with good cognitive function. Correction was made for within-person variability in GGT levels.

Results: During an average follow-up of 22 years, 219 new cases of dementia were recorded. Serum GGT was log-linearly associated with risk of dementia. The hazard ratio (HR) (95% CIs) for dementia per 1 standard deviation (SD) higher baseline loge GGT values was 1.33 (95% CI = 1.14–1.55) after adjustment for several established and emerging risk factors. The corresponding HR was 1.52 (95% CI = 1.22–1.89) after correction for within-person variability.

Discussion: GGT is positively, log-linearly, and independently associated with future risk of dementia in the general male population. Further research is needed to unravel the mechanistic pathways of GGT in the pathogenesis of dementia.
Original languageEnglish
Pages (from-to)931-941
Number of pages11
JournalAlzheimer's and Dementia
Volume12
Issue number9
Early online date18 Apr 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Gamma glutamyltransferase
  • Risk factor
  • Dementia

Fingerprint Dive into the research topics of 'Gamma glutamyltransferase and risk of future dementia in middle-aged to older Finnish men: A new prospective cohort study'. Together they form a unique fingerprint.

Cite this