Gene detection and expression profiling of Neisseria meningitidis using NanoString nCounter platform

Yenenesh K Tekletsion*, Hannah Christensen, Adam Finn

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
235 Downloads (Pure)

Abstract

Detection of bacterial gene transcripts in low density mucosal samples is challenging. We evaluated the NanoString nCounter system for transcript detection in Neisseria meningitidis (Nm) cultures. The method was sensitive, reproducible (R2 = 0.99) and demonstrated changes in gene expression. Studying Nm transcripts from pharyngeal samples may be feasible using this approach.
Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalJournal of Microbiological Methods
Volume146
Early online date7 Feb 2018
DOIs
Publication statusPublished - Mar 2018

Keywords

  • Transcriptomics
  • NanoString
  • Gene expression
  • Neisseria meningitidis
  • mRNA

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