Gene-environment equivalence: The fundamental principle of Mendelian randomization

George Davey Smith; Gibran Hemani; Shah Ebrahim

doi:10.1371/journal.pmed.1005013

Gene-environment equivalence: The fundamental principle of Mendelian randomization

George Davey Smith^*, Gibran Hemani, Shah Ebrahim

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal)

1 Citation (Scopus)

Abstract

The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers, and editors of gene-environment equivalence, the fundamental principle of MR.

Original language	English
Article number	e1005013
Number of pages	5
Journal	PLOS Medicine
Volume	23
Issue number	3
DOIs	https://doi.org/10.1371/journal.pmed.1005013
Publication status	Published - 13 Mar 2026

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© 2026 Davey Smith et al.

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Bristol Population Health Science Institute

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Integrative Epidemiology Unit
Davey Smith, G. (Principal Investigator)
1/04/23 → 31/03/28
Project: Research

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title = "Gene-environment equivalence: The fundamental principle of Mendelian randomization",

abstract = "The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers, and editors of gene-environment equivalence, the fundamental principle of MR.",

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JO - PLOS Medicine

JF - PLOS Medicine

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Gene-environment equivalence: The fundamental principle of Mendelian randomization

Abstract

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Integrative Epidemiology Unit

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