Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone

Lei Liu, Elizabeth A Walker, Stephen Kissane, Imran Khan, Philip I Murray, Saaeha Rauz, Graham R Wallace

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)

Abstract

Dexamethasone (DEX) is commonly used as a therapeutic agent for various ocular inflammatory diseases; however, its effect on resident naive cells is unknown. In this study, genome microarray and microRNA (miR) analyses were used to evaluate the global gene and miR expression of human corneal fibroblasts (HKFs) in response to treatment with DEX.
Original languageEnglish
Pages (from-to)7282-8
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number10
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Dexamethasone
  • Genome, Human
  • MicroRNAs
  • Oligonucleotide Array Sequence Analysis
  • Humans
  • Corneal Stroma
  • Reverse Transcriptase Polymerase Chain Reaction
  • Glucocorticoids
  • Fibroblasts
  • Phenotype
  • Gene Expression Profiling
  • Eye Proteins
  • Cells, Cultured
  • Gene Expression Regulation

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