Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone

Lei Liu; Elizabeth A Walker; Stephen Kissane; Imran Khan; Philip I Murray; Saaeha Rauz; Graham R Wallace

doi:10.1167/iovs.11-7463

Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone

Lei Liu, Elizabeth A Walker, Stephen Kissane, Imran Khan, Philip I Murray, Saaeha Rauz, Graham R Wallace

Research output: Contribution to journal › Article (Academic Journal) › peer-review

20 Citations (Scopus)

Abstract

Dexamethasone (DEX) is commonly used as a therapeutic agent for various ocular inflammatory diseases; however, its effect on resident naive cells is unknown. In this study, genome microarray and microRNA (miR) analyses were used to evaluate the global gene and miR expression of human corneal fibroblasts (HKFs) in response to treatment with DEX.

Original language	English
Pages (from-to)	7282-8
Number of pages	7
Journal	Investigative Ophthalmology and Visual Science
Volume	52
Issue number	10
DOIs	https://doi.org/10.1167/iovs.11-7463
Publication status	Published - Sept 2011

Keywords

Dexamethasone
Genome, Human
MicroRNAs
Oligonucleotide Array Sequence Analysis
Humans
Corneal Stroma
Reverse Transcriptase Polymerase Chain Reaction
Glucocorticoids
Fibroblasts
Phenotype
Gene Expression Profiling
Eye Proteins
Cells, Cultured
Gene Expression Regulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone",

abstract = "Dexamethasone (DEX) is commonly used as a therapeutic agent for various ocular inflammatory diseases; however, its effect on resident naive cells is unknown. In this study, genome microarray and microRNA (miR) analyses were used to evaluate the global gene and miR expression of human corneal fibroblasts (HKFs) in response to treatment with DEX.",

keywords = "Dexamethasone, Genome, Human, MicroRNAs, Oligonucleotide Array Sequence Analysis, Humans, Corneal Stroma, Reverse Transcriptase Polymerase Chain Reaction, Glucocorticoids, Fibroblasts, Phenotype, Gene Expression Profiling, Eye Proteins, Cells, Cultured, Gene Expression Regulation",

author = "Lei Liu and Walker, {Elizabeth A} and Stephen Kissane and Imran Khan and Murray, {Philip I} and Saaeha Rauz and Wallace, {Graham R}",

year = "2011",

month = sep,

doi = "10.1167/iovs.11-7463",

language = "English",

volume = "52",

pages = "7282--8",

journal = "Investigative Ophthalmology and Visual Science",

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publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "10",

}

TY - JOUR

T1 - Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone

AU - Liu, Lei

AU - Walker, Elizabeth A

AU - Kissane, Stephen

AU - Khan, Imran

AU - Murray, Philip I

AU - Rauz, Saaeha

AU - Wallace, Graham R

PY - 2011/9

Y1 - 2011/9

N2 - Dexamethasone (DEX) is commonly used as a therapeutic agent for various ocular inflammatory diseases; however, its effect on resident naive cells is unknown. In this study, genome microarray and microRNA (miR) analyses were used to evaluate the global gene and miR expression of human corneal fibroblasts (HKFs) in response to treatment with DEX.

AB - Dexamethasone (DEX) is commonly used as a therapeutic agent for various ocular inflammatory diseases; however, its effect on resident naive cells is unknown. In this study, genome microarray and microRNA (miR) analyses were used to evaluate the global gene and miR expression of human corneal fibroblasts (HKFs) in response to treatment with DEX.

KW - Dexamethasone

KW - Genome, Human

KW - MicroRNAs

KW - Oligonucleotide Array Sequence Analysis

KW - Humans

KW - Corneal Stroma

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Glucocorticoids

KW - Fibroblasts

KW - Phenotype

KW - Gene Expression Profiling

KW - Eye Proteins

KW - Cells, Cultured

KW - Gene Expression Regulation

U2 - 10.1167/iovs.11-7463

DO - 10.1167/iovs.11-7463

M3 - Article (Academic Journal)

C2 - 21666241

SN - 1552-5783

VL - 52

SP - 7282

EP - 7288

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 10

ER -

Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone

Abstract

Keywords

UN SDGs

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