Gene-Mediated Chemical Communication in Synthetic Protocell Communities

T. Y.Dora Tang*, Dario Cecchi, Giorgio Fracasso, Davide Accardi, Angelique Coutable-Pennarun, Sheref S. Mansy, Adam W. Perriman, J. L.Ross Anderson, Stephen Mann

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)peer-review

116 Citations (Scopus)
501 Downloads (Pure)


A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.
Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalACS Synthetic Biology
Issue number2
Early online date1 Nov 2017
Publication statusPublished - 16 Feb 2018

Structured keywords

  • BrisSynBio
  • Bristol BioDesign Institute


  • cell-free expression
  • communication
  • enzyme cascade
  • genetic switches
  • lipid vesicles
  • proteinosomes
  • α-hemolysin


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